Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1665759..1666271 Replicon chromosome
Accession NZ_CP089949
Organism Streptococcus pneumoniae strain SN75752

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag LXA49_RS08465 Protein ID WP_000924721.1
Coordinates 1665759..1666013 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag LXA49_RS08470 Protein ID WP_000388572.1
Coordinates 1666017..1666271 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXA49_RS08450 (LXA49_08440) 1662860..1663174 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
LXA49_RS08455 (LXA49_08445) 1663199..1663825 - 627 WP_000775037.1 guanylate kinase -
LXA49_RS08460 (LXA49_08450) 1663955..1665568 - 1614 WP_000404929.1 ribonuclease Y -
LXA49_RS08465 (LXA49_08455) 1665759..1666013 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
LXA49_RS08470 (LXA49_08460) 1666017..1666271 - 255 WP_000388572.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LXA49_RS08475 (LXA49_08465) 1666509..1667606 - 1098 WP_000156323.1 nucleotidyltransferase -
LXA49_RS08480 (LXA49_08470) 1667630..1669441 - 1812 WP_001025033.1 NACHT domain-containing protein -
LXA49_RS08485 (LXA49_08475) 1669482..1670222 - 741 WP_000257068.1 class I SAM-dependent methyltransferase -
LXA49_RS08490 (LXA49_08480) 1670542..1670895 - 354 WP_001003001.1 ribosome silencing factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T229793 WP_000924721.1 NZ_CP089949:c1666013-1665759 [Streptococcus pneumoniae]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

>T229793 NZ_CP124517:3841451-3841801 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT229793 WP_000388572.1 NZ_CP089949:c1666271-1666017 [Streptococcus pneumoniae]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp

>AT229793 NZ_CP124517:3841206-3841457 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB K0ZY22

References