Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/HicA-HicB |
Location | 1696492..1697160 | Replicon | chromosome |
Accession | NZ_CP089948 | ||
Organism | Streptococcus pneumoniae TIGR4 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | A0A0B7M7X4 |
Locus tag | LXA46_RS08385 | Protein ID | WP_001132284.1 |
Coordinates | 1696981..1697160 (-) | Length | 60 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | G0IC64 |
Locus tag | LXA46_RS08380 | Protein ID | WP_000961810.1 |
Coordinates | 1696492..1696944 (-) | Length | 151 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LXA46_RS08355 (LXA46_08345) | 1692384..1693127 | - | 744 | WP_001188203.1 | 16S rRNA (uracil(1498)-N(3))-methyltransferase | - |
LXA46_RS08360 (LXA46_08350) | 1693129..1694079 | - | 951 | WP_000451153.1 | 50S ribosomal protein L11 methyltransferase | - |
LXA46_RS08365 (LXA46_08355) | 1694215..1694643 | - | 429 | WP_000418173.1 | NUDIX hydrolase | - |
LXA46_RS08370 (LXA46_08360) | 1694624..1695712 | - | 1089 | WP_000719713.1 | site-2 protease family protein | - |
LXA46_RS08375 (LXA46_08365) | 1695731..1696201 | - | 471 | WP_000257087.1 | DUF3013 family protein | - |
LXA46_RS08380 (LXA46_08370) | 1696492..1696944 | - | 453 | WP_000961810.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
LXA46_RS08385 (LXA46_08375) | 1696981..1697160 | - | 180 | WP_001132284.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
LXA46_RS08390 (LXA46_08380) | 1697297..1697476 | - | 180 | WP_001048906.1 | hypothetical protein | - |
LXA46_RS08395 (LXA46_08385) | 1697641..1697862 | - | 222 | WP_000425689.1 | hypothetical protein | - |
LXA46_RS08400 (LXA46_08390) | 1698154..1699425 | + | 1272 | WP_001113214.1 | replication-associated recombination protein A | - |
LXA46_RS08410 (LXA46_08400) | 1699982..1701238 | - | 1257 | WP_000436400.1 | ISL3 family transposase | - |
LXA46_RS08415 (LXA46_08405) | 1701544..1702119 | - | 576 | WP_000810872.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
flank | IS/Tn | - | - | 1699982..1701238 | 1256 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 60 a.a. Molecular weight: 6713.95 Da Isoelectric Point: 11.0174
>T229790 WP_001132284.1 NZ_CP089948:c1697160-1696981 [Streptococcus pneumoniae TIGR4]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGELNKYTERGIRKQAGL
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGELNKYTERGIRKQAGL
Download Length: 180 bp
>T229790 NZ_CP124517:c3011417-3011310 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
Antitoxin
Download Length: 151 a.a. Molecular weight: 16659.46 Da Isoelectric Point: 3.7220
>AT229790 WP_000961810.1 NZ_CP089948:c1696944-1696492 [Streptococcus pneumoniae TIGR4]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA
Download Length: 453 bp
>AT229790 NZ_CP124517:3011466-3011531 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0B7M7X4 |
Antitoxin
Source | ID | Structure |
---|---|---|
PDB | 5YRZ | |
AlphaFold DB | G0IC64 |