Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-RelB |
Location | 1645310..1645822 | Replicon | chromosome |
Accession | NZ_CP089948 | ||
Organism | Streptococcus pneumoniae TIGR4 |
Toxin (Protein)
Gene name | yoeB | Uniprot ID | Q8DNR3 |
Locus tag | LXA46_RS08135 | Protein ID | WP_000924721.1 |
Coordinates | 1645310..1645564 (-) | Length | 85 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | K0ZY22 |
Locus tag | LXA46_RS08140 | Protein ID | WP_000388572.1 |
Coordinates | 1645568..1645822 (-) | Length | 85 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LXA46_RS08120 (LXA46_08110) | 1642411..1642725 | - | 315 | WP_000979235.1 | DNA-directed RNA polymerase subunit omega | - |
LXA46_RS08125 (LXA46_08115) | 1642750..1643376 | - | 627 | WP_000775037.1 | guanylate kinase | - |
LXA46_RS08130 (LXA46_08120) | 1643506..1645119 | - | 1614 | WP_000404940.1 | ribonuclease Y | - |
LXA46_RS08135 (LXA46_08125) | 1645310..1645564 | - | 255 | WP_000924721.1 | Txe/YoeB family addiction module toxin | Toxin |
LXA46_RS08140 (LXA46_08130) | 1645568..1645822 | - | 255 | WP_000388572.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
LXA46_RS08145 (LXA46_08135) | 1646060..1647157 | - | 1098 | WP_000156358.1 | nucleotidyltransferase | - |
LXA46_RS08150 (LXA46_08140) | 1647167..1647907 | - | 741 | WP_000257069.1 | class I SAM-dependent methyltransferase | - |
LXA46_RS08155 (LXA46_08145) | 1648016..1648369 | - | 354 | WP_001003023.1 | ribosome silencing factor | - |
LXA46_RS08160 (LXA46_08150) | 1648382..1648882 | - | 501 | WP_000844707.1 | cysteine hydrolase family protein | - |
LXA46_RS08165 (LXA46_08155) | 1648883..1649476 | - | 594 | WP_000121667.1 | bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK | - |
LXA46_RS08170 (LXA46_08160) | 1649476..1650105 | - | 630 | WP_000151313.1 | nicotinate-nucleotide adenylyltransferase | - |
LXA46_RS08175 (LXA46_08165) | 1650157..1650468 | - | 312 | WP_000060169.1 | ribosome assembly RNA-binding protein YhbY | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10115.55 Da Isoelectric Point: 7.9716
>T229789 WP_000924721.1 NZ_CP089948:c1645564-1645310 [Streptococcus pneumoniae TIGR4]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY
Download Length: 255 bp
>T229789 NZ_CP124517:c3010934-3010827 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA
Antitoxin
Download Length: 85 a.a. Molecular weight: 9706.00 Da Isoelectric Point: 4.8430
>AT229789 WP_000388572.1 NZ_CP089948:c1645822-1645568 [Streptococcus pneumoniae TIGR4]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE
Download Length: 255 bp
>AT229789 NZ_CP124517:3010991-3011048 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0B7LEN4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | K0ZY22 |