Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1645310..1645822 Replicon chromosome
Accession NZ_CP089948
Organism Streptococcus pneumoniae TIGR4

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag LXA46_RS08135 Protein ID WP_000924721.1
Coordinates 1645310..1645564 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag LXA46_RS08140 Protein ID WP_000388572.1
Coordinates 1645568..1645822 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXA46_RS08120 (LXA46_08110) 1642411..1642725 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
LXA46_RS08125 (LXA46_08115) 1642750..1643376 - 627 WP_000775037.1 guanylate kinase -
LXA46_RS08130 (LXA46_08120) 1643506..1645119 - 1614 WP_000404940.1 ribonuclease Y -
LXA46_RS08135 (LXA46_08125) 1645310..1645564 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
LXA46_RS08140 (LXA46_08130) 1645568..1645822 - 255 WP_000388572.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LXA46_RS08145 (LXA46_08135) 1646060..1647157 - 1098 WP_000156358.1 nucleotidyltransferase -
LXA46_RS08150 (LXA46_08140) 1647167..1647907 - 741 WP_000257069.1 class I SAM-dependent methyltransferase -
LXA46_RS08155 (LXA46_08145) 1648016..1648369 - 354 WP_001003023.1 ribosome silencing factor -
LXA46_RS08160 (LXA46_08150) 1648382..1648882 - 501 WP_000844707.1 cysteine hydrolase family protein -
LXA46_RS08165 (LXA46_08155) 1648883..1649476 - 594 WP_000121667.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
LXA46_RS08170 (LXA46_08160) 1649476..1650105 - 630 WP_000151313.1 nicotinate-nucleotide adenylyltransferase -
LXA46_RS08175 (LXA46_08165) 1650157..1650468 - 312 WP_000060169.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T229789 WP_000924721.1 NZ_CP089948:c1645564-1645310 [Streptococcus pneumoniae TIGR4]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

>T229789 NZ_CP124517:c3010934-3010827 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT229789 WP_000388572.1 NZ_CP089948:c1645822-1645568 [Streptococcus pneumoniae TIGR4]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp

>AT229789 NZ_CP124517:3010991-3011048 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB K0ZY22

References