Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | DinJ-YafQ (relBE)/YafQ-RelB |
| Location | 3123080..3123625 | Replicon | chromosome |
| Accession | NZ_CP089940 | ||
| Organism | Erwinia tracheiphila strain BuffGH | ||
Toxin (Protein)
| Gene name | yafQ | Uniprot ID | - |
| Locus tag | LU631_RS16645 | Protein ID | WP_232426821.1 |
| Coordinates | 3123080..3123280 (-) | Length | 67 a.a. |
Antitoxin (Protein)
| Gene name | dinJ | Uniprot ID | A0A0M2KC92 |
| Locus tag | LU631_RS16650 | Protein ID | WP_016189579.1 |
| Coordinates | 3123365..3123625 (-) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LU631_RS16610 (LU631_16610) | 3118417..3119090 | + | 674 | Protein_3281 | IS1 family transposase | - |
| LU631_RS16615 (LU631_16615) | 3119996..3120619 | + | 624 | WP_016189571.1 | hypothetical protein | - |
| LU631_RS16620 (LU631_16620) | 3120662..3121072 | + | 411 | WP_016189572.1 | lysozyme inhibitor LprI family protein | - |
| LU631_RS16625 (LU631_16625) | 3121132..3121548 | + | 417 | WP_016189573.1 | hypothetical protein | - |
| LU631_RS16630 (LU631_16630) | 3121743..3122078 | + | 336 | WP_016189574.1 | hypothetical protein | - |
| LU631_RS16635 (LU631_16635) | 3122193..3122703 | + | 511 | Protein_3286 | DUF2778 domain-containing protein | - |
| LU631_RS16640 (LU631_16640) | 3122681..3122956 | + | 276 | WP_016189577.1 | hypothetical protein | - |
| LU631_RS16645 (LU631_16645) | 3123080..3123280 | - | 201 | WP_232426821.1 | type II toxin-antitoxin system YafQ family toxin | Toxin |
| LU631_RS16650 (LU631_16650) | 3123365..3123625 | - | 261 | WP_016189579.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| LU631_RS16655 (LU631_16655) | 3123771..3123944 | + | 174 | WP_016189580.1 | hypothetical protein | - |
| LU631_RS16660 (LU631_16660) | 3124455..3125438 | + | 984 | WP_232426796.1 | hypothetical protein | - |
| LU631_RS16665 (LU631_16665) | 3125517..3125705 | + | 189 | WP_232426797.1 | hypothetical protein | - |
| LU631_RS16670 (LU631_16670) | 3125720..3126841 | + | 1122 | WP_016189581.1 | tail fiber | - |
| LU631_RS16675 (LU631_16675) | 3127137..3127834 | + | 698 | WP_233481924.1 | IS1 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 3120062..3134263 | 14201 | |
| - | flank | IS/Tn | - | - | 3127331..3127834 | 503 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 67 a.a. Molecular weight: 7685.87 Da Isoelectric Point: 7.3142
>T229760 WP_232426821.1 NZ_CP089940:c3123280-3123080 [Erwinia tracheiphila]
ISKLKTLMTLLINGSLPLPAEYKDHPLQGNYKGYRDAHIEPDWLLIYKITDNLLRFERTGTHSDLF
ISKLKTLMTLLINGSLPLPAEYKDHPLQGNYKGYRDAHIEPDWLLIYKITDNLLRFERTGTHSDLF
Download Length: 201 bp
>T229760 NZ_CP124515:c825580-825203 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCAACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAAAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCAACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAAAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9259.69 Da Isoelectric Point: 5.8213
>AT229760 WP_016189579.1 NZ_CP089940:c3123625-3123365 [Erwinia tracheiphila]
MAANALVRARIDETLKKEAADVLAGMGLTVSDLVRITLTKVAREKALPFDLRIPNEVTANTITASEKGVDVHQAKNADDL
FDKLGI
MAANALVRARIDETLKKEAADVLAGMGLTVSDLVRITLTKVAREKALPFDLRIPNEVTANTITASEKGVDVHQAKNADDL
FDKLGI
Download Length: 261 bp
>AT229760 NZ_CP124515:c826037-825657 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGGGGCCGGT
TCAACAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGGTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGGGGCCGGT
TCAACAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGGTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|