Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/MqsA(antitoxin)
Location 31942..32593 Replicon plasmid pETR001-b
Accession NZ_CP089935
Organism Erwinia tracheiphila strain SCR3

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LU632_RS25500 Protein ID WP_233480965.1
Coordinates 32249..32593 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LU632_RS25495 Protein ID WP_233480964.1
Coordinates 31942..32256 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LU632_RS25460 (LU632_25460) 27261..28094 - 834 WP_233480958.1 DUF932 domain-containing protein -
LU632_RS25465 (LU632_25465) 28513..28779 - 267 WP_233480959.1 hypothetical protein -
LU632_RS25470 (LU632_25470) 28872..29312 - 441 WP_233480960.1 DUF1419 domain-containing protein -
LU632_RS25475 (LU632_25475) 29278..29436 - 159 WP_233480961.1 hypothetical protein -
LU632_RS25480 (LU632_25480) 29942..30181 + 240 WP_233480962.1 helix-turn-helix transcriptional regulator -
LU632_RS25485 (LU632_25485) 30743..30889 - 147 Protein_32 hypothetical protein -
LU632_RS25490 (LU632_25490) 30946..31524 - 579 WP_233480963.1 antirestriction protein -
LU632_RS25495 (LU632_25495) 31942..32256 - 315 WP_233480964.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
LU632_RS25500 (LU632_25500) 32249..32593 - 345 WP_233480965.1 toxin Toxin
LU632_RS25505 (LU632_25505) 32846..33148 - 303 WP_233480966.1 methyltransferase -
LU632_RS25510 (LU632_25510) 33297..33560 - 264 Protein_37 transposase -
LU632_RS25515 (LU632_25515) 33649..34872 + 1224 WP_233480488.1 IS91 family transposase -
LU632_RS25520 (LU632_25520) 35506..36774 + 1269 WP_233480901.1 aspartate aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..68396 68396


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(43-88)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13723.68 Da        Isoelectric Point: 9.8634

>T229746 WP_233480965.1 NZ_CP089935:c32593-32249 [Erwinia tracheiphila]
MYALFIELSSFEKYRANYLNDDQFRLFQRMLLADPEKGDLIPDTGGLRKVRYRDERRNKGTRGGIRVIYYWTNEKGQFIL
FTIYDKEQRDDLTKQQRDALAEALSVIKKRLKYE

Download         Length: 345 bp

>T229746 NZ_CP124513:c3596062-3595760 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12095.76 Da        Isoelectric Point: 7.3163

>AT229746 WP_233480964.1 NZ_CP089935:c32256-31942 [Erwinia tracheiphila]
MNERDIYSELMTGMQELKDHQDGKITLKTYKVSKREPVTIAPQELRDVREKLNLSQAVFAHYLHTGETTYQNWEQGRARP
NAQAVLLIRMVQQNPETLQTLAQL

Download         Length: 315 bp

>AT229746 NZ_CP124513:c3595724-3595383 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References