Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 2858737..2859282 Replicon chromosome
Accession NZ_CP089932
Organism Erwinia tracheiphila strain BHKY

Toxin (Protein)


Gene name yafQ Uniprot ID -
Locus tag LU633_RS15105 Protein ID WP_232426821.1
Coordinates 2858737..2858937 (-) Length 67 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A0M2KC92
Locus tag LU633_RS15110 Protein ID WP_016189579.1
Coordinates 2859022..2859282 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LU633_RS15070 (LU633_15070) 2854074..2854747 + 674 Protein_2966 IS1 family transposase -
LU633_RS15075 (LU633_15075) 2855653..2856276 + 624 WP_016189571.1 hypothetical protein -
LU633_RS15080 (LU633_15080) 2856319..2856729 + 411 WP_016189572.1 lysozyme inhibitor LprI family protein -
LU633_RS15085 (LU633_15085) 2856789..2857205 + 417 WP_016189573.1 hypothetical protein -
LU633_RS15090 (LU633_15090) 2857400..2857735 + 336 WP_016189574.1 hypothetical protein -
LU633_RS15095 (LU633_15095) 2857850..2858360 + 511 Protein_2971 DUF2778 domain-containing protein -
LU633_RS15100 (LU633_15100) 2858338..2858613 + 276 WP_016189577.1 hypothetical protein -
LU633_RS15105 (LU633_15105) 2858737..2858937 - 201 WP_232426821.1 type II toxin-antitoxin system YafQ family toxin Toxin
LU633_RS15110 (LU633_15110) 2859022..2859282 - 261 WP_016189579.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LU633_RS15115 (LU633_15115) 2859428..2859601 + 174 WP_016189580.1 hypothetical protein -
LU633_RS15120 (LU633_15120) 2860112..2861095 + 984 WP_232426796.1 hypothetical protein -
LU633_RS15125 (LU633_15125) 2861174..2861362 + 189 WP_232426797.1 hypothetical protein -
LU633_RS15130 (LU633_15130) 2861377..2862498 + 1122 WP_016189581.1 tail fiber -
LU633_RS15135 (LU633_15135) 2862794..2863491 + 698 WP_233481924.1 IS1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2855719..2869920 14201
- flank IS/Tn - - 2862988..2863491 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-66)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 67 a.a.        Molecular weight: 7685.87 Da        Isoelectric Point: 7.3142

>T229721 WP_232426821.1 NZ_CP089932:c2858937-2858737 [Erwinia tracheiphila]
ISKLKTLMTLLINGSLPLPAEYKDHPLQGNYKGYRDAHIEPDWLLIYKITDNLLRFERTGTHSDLF

Download         Length: 201 bp

>T229721 NZ_CP124511:3154774-3154881 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9259.69 Da        Isoelectric Point: 5.8213

>AT229721 WP_016189579.1 NZ_CP089932:c2859282-2859022 [Erwinia tracheiphila]
MAANALVRARIDETLKKEAADVLAGMGLTVSDLVRITLTKVAREKALPFDLRIPNEVTANTITASEKGVDVHQAKNADDL
FDKLGI

Download         Length: 261 bp

>AT229721 NZ_CP124511:c3154725-3154660 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2KC92

References