Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5194631..5195226 Replicon chromosome
Accession NC_011004
Organism Rhodopseudomonas palustris TIE-1

Toxin (Protein)


Gene name graT Uniprot ID B3Q7W1
Locus tag RPAL_RS23875 Protein ID WP_012497552.1
Coordinates 5194631..5194909 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag RPAL_RS23880 Protein ID WP_012497553.1
Coordinates 5194921..5195226 (+) Length 102 a.a.

Genomic Context

RPAL_RS23860RPAL_RS23865RPAL_RS23870RPAL_RS23875RPAL_RS23880RPAL_RS23895RPAL_RS23900RPAL_RS23905RPAL_RS23885RPAL_RS23890RPAL_RS27885
Location: 5190666..5193701 (3036 bp)
Type: Others
Protein ID: WP_012497550.1
Location: 5193792..5194025 (234 bp)
Type: Others
Protein ID: WP_011159878.1
Location: 5194026..5194220 (195 bp)
Type: Others
Protein ID: WP_012497551.1
Location: 5194631..5194909 (279 bp)
Type: Toxin
Protein ID: WP_012497552.1
Location: 5194921..5195226 (306 bp)
Type: Antitoxin
Protein ID: WP_012497553.1
Location: 5197549..5197983 (435 bp)
Type: Others
Protein ID: WP_012497556.1
Location: 5198467..5198898 (432 bp)
Type: Others
Protein ID: WP_012497557.1
Location: 5199106..5199546 (441 bp)
Type: Others
Protein ID: WP_012497558.1
Location: 5195340..5195693 (354 bp)
Type: Others
Protein ID: WP_150104575.1
Location: 5196082..5197335 (1254 bp)
Type: Others
Protein ID: WP_012497555.1
Location: 5199696..5199842 (147 bp)
Type: Others
Protein ID: WP_011159884.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
RPAL_RS238605190666..5193701+3036WP_012497550.1excinuclease ABC subunit UvrB-
RPAL_RS238655193792..5194025+234WP_011159878.1DUF1902 domain-containing protein-
RPAL_RS238705194026..5194220+195WP_012497551.1type II toxin-antitoxin system HicA family toxin-
RPAL_RS238755194631..5194909+279WP_012497552.1type II toxin-antitoxin system RelE/ParE family toxinToxin
RPAL_RS238805194921..5195226+306WP_012497553.1HigA family addiction module antidote proteinAntitoxin
RPAL_RS238855195340..5195693-354WP_150104575.1(2Fe-2S) ferredoxin domain-containing protein-
RPAL_RS238905196082..5197335-1254WP_012497555.1acetyl-CoA C-acetyltransferase-
RPAL_RS238955197549..5197983+435WP_012497556.1hypothetical protein-
RPAL_RS239005198467..5198898+432WP_012497557.1nuclear transport factor 2 family protein-
RPAL_RS239055199106..5199546+441WP_012497558.1hypothetical protein-
RPAL_RS278855199696..5199842-147WP_011159884.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10913.43 Da        Isoelectric Point: 9.0805

>T22969 WP_012497552.1 NC_011004:5194631-5194909 [Rhodopseudomonas palustris TIE-1]
MIRSFRNPATARLFADEDVPRFRAIERQARRKLLLLDGAAKLDDLRQPPGNRLEALKGDRRGQYSIRINDQWRICFEWRE
DGAEMVEIVDYH

Download         Length: 279 bp

>T22969 NC_011004:5194631-5194909 [Rhodopseudomonas palustris TIE-1]
ATGATCCGCTCGTTCCGAAATCCGGCGACCGCGCGGCTGTTTGCTGATGAGGACGTGCCGCGGTTTCGCGCGATCGAGCG
GCAGGCTCGTCGAAAGCTGCTGCTCCTGGACGGCGCCGCCAAACTCGACGATTTGCGGCAACCTCCCGGCAACAGGCTCG
AGGCTTTGAAGGGCGATCGCCGCGGCCAATACTCGATCCGCATCAACGATCAATGGCGGATTTGCTTCGAGTGGCGTGAG
GACGGCGCCGAAATGGTTGAAATCGTGGACTATCATTAG

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11312.14 Da        Isoelectric Point: 10.2943

>AT22969 WP_012497553.1 NC_011004:5194921-5195226 [Rhodopseudomonas palustris TIE-1]
MAKPKQLPPIPPGEILIEEFMRPNGISQNRLARDIDINPARVNDIVHGRSAITAAVALRLAKYFGTTPELWMNLQASYDL
RRARAADWPAIEPRVRVLAAE

Download         Length: 306 bp

>AT22969 NC_011004:5194921-5195226 [Rhodopseudomonas palustris TIE-1]
ATGGCCAAACCAAAGCAGCTCCCCCCGATCCCTCCCGGCGAGATTCTGATCGAGGAATTCATGCGCCCGAACGGGATCAG
TCAGAACCGGCTGGCACGCGATATCGACATCAACCCGGCTCGGGTCAACGACATCGTGCACGGCCGCTCTGCGATCACCG
CCGCAGTCGCCCTGCGGCTGGCGAAGTACTTCGGCACGACGCCCGAACTCTGGATGAACTTGCAGGCGTCCTACGACCTC
CGCCGTGCCCGCGCCGCGGACTGGCCCGCCATCGAGCCGCGCGTCCGCGTGCTCGCCGCAGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A2R4GZL3

Antitoxin

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Source
ID
Structure
No matching records found

References