Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 734698..735473 Replicon chromosome
Accession NZ_CP089926
Organism Klebsiella pneumoniae strain KP111

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag LVQ71_RS03645 Protein ID WP_060568463.1
Coordinates 734988..735473 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag LVQ71_RS03640 Protein ID WP_004150912.1
Coordinates 734698..734991 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVQ71_RS03620 (729906) 729906..730508 - 603 WP_004174410.1 short chain dehydrogenase -
LVQ71_RS03625 (730606) 730606..731517 + 912 WP_023342207.1 LysR family transcriptional regulator -
LVQ71_RS03630 (731518) 731518..732666 - 1149 WP_016947441.1 PLP-dependent aspartate aminotransferase family protein -
LVQ71_RS03635 (732677) 732677..734053 - 1377 WP_004174417.1 pyridoxal-phosphate dependent enzyme -
LVQ71_RS03640 (734698) 734698..734991 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
LVQ71_RS03645 (734988) 734988..735473 + 486 WP_060568463.1 GNAT family N-acetyltransferase Toxin
LVQ71_RS03650 (736177) 736177..736770 + 594 WP_004188553.1 hypothetical protein -
LVQ71_RS03655 (736867) 736867..737083 + 217 Protein_718 transposase -
LVQ71_RS03665 (738576) 738576..739289 - 714 WP_002916694.1 DUF554 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 736867..737019 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17602.64 Da        Isoelectric Point: 8.1629

>T229632 WP_060568463.1 NZ_CP089926:734988-735473 [Klebsiella pneumoniae]
MILAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRHNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

>T229632 NZ_CP124500:2723104-2723211 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT229632 WP_004150912.1 NZ_CP089926:734698-734991 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT229632 NZ_CP124500:c2723047-2722992 [Escherichia coli]
CAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References