Detailed information of TA system TA229626

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/MqsA(antitoxin)
• Location: 3664827..3665482
• Replicon: chromosome
• Accession: NZ_CP089919
• Organism: Rahnella victoriana strain JZ-GX1

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: J9880_RS16955
• Protein ID: WP_095922304.1
• Coordinates: 3664827..3665165 (+)
• Length: 113 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: J9880_RS16960
• Protein ID: WP_095922303.1
• Coordinates: 3665162..3665482 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J9880_RS16935 (J9880_16935)	3659852..3660403	-	552	WP_095922309.1	tyrosine-type DNA invertase	-
J9880_RS16940 (J9880_16940)	3660987..3662141	+	1155	WP_095922308.1	flagellar biosynthesis protein FlhB	-
J9880_RS16945 (J9880_16945)	3662134..3664218	+	2085	WP_095922307.1	flagellar biosynthesis protein FlhA	-
J9880_RS16950 (J9880_16950)	3664220..3664636	+	417	WP_119822403.1	flagellar protein FlhE	-
J9880_RS16955 (J9880_16955)	3664827..3665165	+	339	WP_095922304.1	toxin	Toxin
J9880_RS16960 (J9880_16960)	3665162..3665482	+	321	WP_095922303.1	transcriptional regulator	Antitoxin
J9880_RS16965 (J9880_16965)	3665548..3665985	-	438	WP_119822404.1	flagellar export chaperone FlgN	-
J9880_RS16970 (J9880_16970)	3666035..3666337	-	303	WP_095922301.1	flagellar biosynthesis anti-sigma factor FlgM	-
J9880_RS16975 (J9880_16975)	3666500..3667225	-	726	WP_232769654.1	flagellar basal body P-ring formation chaperone FlgA	-
J9880_RS16980 (J9880_16980)	3667390..3667800	+	411	WP_095922299.1	flagellar basal body rod protein FlgB	-
J9880_RS16985 (J9880_16985)	3667806..3668210	+	405	WP_013575164.1	flagellar basal body rod protein FlgC	-
J9880_RS16990 (J9880_16990)	3668222..3668923	+	702	WP_119822406.1	flagellar hook assembly protein FlgD	-
J9880_RS16995 (J9880_16995)	3669000..3670247	+	1248	WP_095922297.1	flagellar hook protein FlgE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (46-89)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 13055.38 Da
• Isoelectric Point: 10.3341

>T229626 WP_095922304.1 NZ_CP089919:3664827-3665165 [Rahnella victoriana]
MKAVFVELPVFEAHRSAYLTDDEYRILQNALLLFPTCGDVIMHTGGLRKLRFPDRQRNKGKRGGTRIIYYWWVAKAHFLL
ITVYGKGEMDDLTFAQKKMLGLLLKQHKAKQE

Nucleotide

• Length: 339 bp

>T229626 NZ_CP124500:1009759-1010166 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 11960.78 Da
• Isoelectric Point: 9.5338

>AT229626 WP_095922303.1 NZ_CP089919:3665162-3665482 [Rahnella victoriana]
MTMKRDLFAEIADGLNAWGEAGQGKRTLKTVERTVGREVRLSAVELKEIRENLNISQAVFAYYLQTALTTYQNWEQGRAK
PNRQAILLIKLVEKDPATLEQLAGLV

Nucleotide

• Length: 321 bp

>AT229626 NZ_CP124500:1009512-1009778 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCACCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA