Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2509188..2509762 Replicon chromosome
Accession NZ_CP089919
Organism Rahnella victoriana strain JZ-GX1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag J9880_RS11620 Protein ID WP_095923274.1
Coordinates 2509484..2509762 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag J9880_RS11615 Protein ID WP_095923275.1
Coordinates 2509188..2509484 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9880_RS11600 (J9880_11600) 2505643..2506383 - 741 WP_119822865.1 GntR family transcriptional regulator -
J9880_RS11605 (J9880_11605) 2506561..2508315 - 1755 WP_119822863.1 ABC transporter ATP-binding protein/permease -
J9880_RS11610 (J9880_11610) 2508445..2509161 + 717 WP_095923276.1 tetratricopeptide repeat protein -
J9880_RS11615 (J9880_11615) 2509188..2509484 - 297 WP_095923275.1 HigA family addiction module antitoxin Antitoxin
J9880_RS11620 (J9880_11620) 2509484..2509762 - 279 WP_095923274.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J9880_RS11625 (J9880_11625) 2509878..2510210 - 333 WP_232769355.1 DUF805 domain-containing protein -
J9880_RS11630 (J9880_11630) 2510484..2511353 - 870 WP_232769356.1 MBL fold metallo-hydrolase -
J9880_RS11635 (J9880_11635) 2511469..2512386 + 918 WP_119822857.1 LysR family transcriptional regulator -
J9880_RS11640 (J9880_11640) 2512605..2513768 + 1164 WP_119822850.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-67)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10462.89 Da        Isoelectric Point: 10.0948

>T229623 WP_095923274.1 NZ_CP089919:c2509762-2509484 [Rahnella victoriana]
MIKDFKHKGLRRFFTSGSTAGINAEHAKKLRLRLATLHSAQAVQDIDRPGYLLHALAGSRKGEWAITVSGNWRLTFEFID
GNAYIVNYEDYH

Download         Length: 279 bp

>T229623 NZ_CP124500:c670545-670081 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10728.43 Da        Isoelectric Point: 6.8787

>AT229623 WP_095923275.1 NZ_CP089919:c2509484-2509188 [Rahnella victoriana]
MNMHNPPHPGELIAETLEELNVSVREFSRALHIAPSTAQRIVSGKMAVTPEMAVKLAAVLGSSAEYWLNLQANRSLWIAE
QTVDISGLHRLAMTLKPA

Download         Length: 297 bp

>AT229623 NZ_CP124500:c670880-670545 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAT
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References