Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 1778160..1778987 Replicon chromosome
Accession NZ_CP089919
Organism Rahnella victoriana strain JZ-GX1

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag J9880_RS08205 Protein ID WP_232770299.1
Coordinates 1778160..1778636 (-) Length 159 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID H2INS2
Locus tag J9880_RS08210 Protein ID WP_014333376.1
Coordinates 1778643..1778987 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9880_RS08175 (J9880_08175) 1774579..1775037 + 459 WP_095923961.1 MarR family transcriptional regulator -
J9880_RS08180 (J9880_08180) 1775171..1775593 + 423 WP_013573432.1 organic hydroperoxide resistance protein -
J9880_RS08185 (J9880_08185) 1775878..1777557 + 1680 WP_119825509.1 kdo(2)-lipid A phosphoethanolamine 7''-transferase -
J9880_RS08205 (J9880_08205) 1778160..1778636 - 477 WP_232770299.1 type II toxin-antitoxin system YhaV family toxin Toxin
J9880_RS08210 (J9880_08210) 1778643..1778987 - 345 WP_014333376.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
J9880_RS08215 (J9880_08215) 1779069..1779224 - 156 WP_014411453.1 type II toxin-antitoxin system RelE/ParE family toxin -
J9880_RS08220 (J9880_08220) 1779371..1780750 - 1380 WP_232770300.1 MmgE/PrpD family protein -
J9880_RS08225 (J9880_08225) 1780770..1781507 - 738 WP_232770452.1 ABC transporter ATP-binding protein -
J9880_RS08230 (J9880_08230) 1781549..1782415 - 867 WP_232770301.1 ABC transporter ATP-binding protein -
J9880_RS08235 (J9880_08235) 1782408..1783343 - 936 WP_133823050.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(13-148)

Antitoxin

SpoVT-AbrB domain

(15-53)


Sequences

Toxin        


Download         Length: 159 a.a.        Molecular weight: 18511.33 Da        Isoelectric Point: 10.2235

>T229621 WP_232770299.1 NZ_CP089919:c1778636-1778160 [Rahnella victoriana]
MHNQAMEINGWTLLAHPLILQQIQALTDQVVLLRRKDPAGYKSKNATKRLAAINKLMFDVIPQDPARVEFRQGDTLGGEF
SHWFRAKFFQQYRLFFRYNLKSRIIIYAWVNDDKELRAYESKTDAYRMFRKMLKSGEPPDNWQALFEASGKVAAEQVP

Download         Length: 477 bp

>T229621 NZ_CP124500:256574-256681 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 12687.45 Da        Isoelectric Point: 4.3324

>AT229621 WP_014333376.1 NZ_CP089919:c1778987-1778643 [Rahnella victoriana]
MSASAVWGIKFEAESKVTRRFQTTIPATIRKALNLTENDRIQYKILPDGQVVISRQLEEAEDPVISAFLGFVAKDMLNNP
ENMQPVTLSLHEKINVLTAGMAIDLESPLSDDDE

Download         Length: 345 bp

>AT229621 NZ_CP124500:c256517-256460 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A4R7GFD4

References