Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 3005841..3006429 Replicon chromosome
Accession NC_011004
Organism Rhodopseudomonas palustris TIE-1

Toxin (Protein)


Gene name graT Uniprot ID B3QH83
Locus tag RPAL_RS13665 Protein ID WP_012495961.1
Coordinates 3005841..3006128 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag RPAL_RS13670 Protein ID WP_012495962.1
Coordinates 3006142..3006429 (+) Length 96 a.a.

Genomic Context

RPAL_RS13640RPAL_RS13650RPAL_RS13665RPAL_RS13670RPAL_RS13680RPAL_RS13685RPAL_RS13645RPAL_RS13655RPAL_RS13660RPAL_RS13675RPAL_RS13690
Location: 3001387..3002892 (1506 bp)
Type: Others
Protein ID: WP_011158030.1
Location: 3003882..3004787 (906 bp)
Type: Others
Protein ID: WP_012495958.1
Location: 3005841..3006128 (288 bp)
Type: Toxin
Protein ID: WP_012495961.1
Location: 3006142..3006429 (288 bp)
Type: Antitoxin
Protein ID: WP_012495962.1
Location: 3008951..3009481 (531 bp)
Type: Others
Protein ID: WP_012495964.1
Location: 3009567..3010556 (990 bp)
Type: Others
Protein ID: WP_012495965.1
Location: 3002947..3003783 (837 bp)
Type: Others
Protein ID: WP_012495957.1
Location: 3004821..3005009 (189 bp)
Type: Others
Protein ID: WP_012495959.1
Location: 3005229..3005699 (471 bp)
Type: Others
Protein ID: WP_012495960.1
Location: 3006442..3008493 (2052 bp)
Type: Others
Protein ID: WP_012495963.1
Location: 3010702..3011247 (546 bp)
Type: Others
Protein ID: WP_012495966.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
RPAL_RS136403001387..3002892+1506WP_011158030.1caspase family protein-
RPAL_RS136453002947..3003783-837WP_012495957.1helix-turn-helix transcriptional regulator-
RPAL_RS136503003882..3004787+906WP_012495958.1SDR family oxidoreductase-
RPAL_RS136553004821..3005009-189WP_012495959.1hypothetical protein-
RPAL_RS136603005229..3005699-471WP_012495960.1hypothetical protein-
RPAL_RS136653005841..3006128+288WP_012495961.1type II toxin-antitoxin system RelE/ParE family toxinToxin
RPAL_RS136703006142..3006429+288WP_012495962.1HigA family addiction module antidote proteinAntitoxin
RPAL_RS136753006442..3008493-2052WP_012495963.1DNA topoisomerase IV subunit B-
RPAL_RS136803008951..3009481+531WP_012495964.1DedA family protein-
RPAL_RS136853009567..3010556+990WP_012495965.1MBL fold metallo-hydrolase-
RPAL_RS136903010702..3011247-546WP_012495966.1DUF2087 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(31-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-59)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11047.69 Da        Isoelectric Point: 10.2688

>T22962 WP_012495961.1 NC_011004:3005841-3006128 [Rhodopseudomonas palustris TIE-1]
MIRSWRNAATRKLWDGSRFDQFRGLDVEAAIDLLLALNAAKSLQDLSPLQSVGLHKLKGVRRNQWAMTVNDRWRICFEFR
KGDAFEVEIVDYHKG

Download         Length: 288 bp

>T22962 NC_011004:3005841-3006128 [Rhodopseudomonas palustris TIE-1]
ATGATCCGGTCATGGCGCAATGCTGCCACCCGGAAGTTATGGGACGGCAGCCGGTTCGACCAATTCCGCGGCCTTGATGT
CGAGGCCGCGATCGATCTGTTGCTGGCTTTGAATGCCGCCAAGTCGCTGCAAGATCTCAGTCCTCTACAGAGCGTAGGAT
TACACAAACTCAAGGGCGTGCGCAGGAACCAATGGGCGATGACGGTCAACGACCGGTGGCGGATTTGTTTCGAGTTTCGC
AAAGGTGATGCGTTCGAAGTCGAGATCGTCGACTATCACAAAGGGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10481.98 Da        Isoelectric Point: 10.6604

>AT22962 WP_012495962.1 NC_011004:3006142-3006429 [Rhodopseudomonas palustris TIE-1]
MAPVSHPGRLLKRELAARKLSANRLALDIGVPSGRITDILNGRRSITADTAVRLGRYFGNAPQFWLDLQSQYDIAVIERD
KGAEIDRQVRPADAA

Download         Length: 288 bp

>AT22962 NC_011004:3006142-3006429 [Rhodopseudomonas palustris TIE-1]
ATGGCTCCTGTTTCCCATCCCGGCCGGCTGCTGAAGCGAGAACTGGCGGCGCGGAAACTCAGCGCCAACCGGCTGGCGCT
GGACATCGGCGTTCCGTCTGGACGGATCACCGACATTCTCAACGGTCGTCGGTCGATTACTGCGGATACCGCGGTGCGGC
TGGGTCGTTATTTCGGAAATGCTCCGCAGTTCTGGCTCGATCTGCAGAGCCAGTACGACATCGCCGTCATCGAGCGTGAC
AAGGGCGCGGAGATTGACCGTCAGGTGCGGCCGGCGGACGCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBB3QH83

Antitoxin

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Source
ID
Structure
No matching records found

References