229574

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 727644..728419 Replicon chromosome
Accession NZ_CP089882
Organism Klebsiella pneumoniae strain KP059

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag LVQ69_RS03605 Protein ID WP_004150910.1
Coordinates 727934..728419 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag LVQ69_RS03600 Protein ID WP_004150912.1
Coordinates 727644..727937 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVQ69_RS03580 (LVQ69_03580) 722852..723454 - 603 WP_020802400.1 short chain dehydrogenase -
LVQ69_RS03585 (LVQ69_03585) 723552..724463 + 912 WP_110218121.1 LysR family transcriptional regulator -
LVQ69_RS03590 (LVQ69_03590) 724464..725612 - 1149 WP_032433524.1 PLP-dependent aspartate aminotransferase family protein -
LVQ69_RS03595 (LVQ69_03595) 725623..726999 - 1377 WP_004181304.1 cystathionine beta-synthase -
LVQ69_RS03600 (LVQ69_03600) 727644..727937 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
LVQ69_RS03605 (LVQ69_03605) 727934..728419 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
LVQ69_RS03610 (LVQ69_03610) 729123..729716 + 594 WP_004188553.1 hypothetical protein -
LVQ69_RS03615 (LVQ69_03615) 729813..730029 + 217 Protein_710 transposase -
LVQ69_RS03625 (LVQ69_03625) 730707..731420 - 714 WP_002916694.1 DUF554 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 729813..729965 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T229574 WP_004150910.1 NZ_CP089882:727934-728419 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

>T229574 NZ_CP124495:188058-188165 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT229574 WP_004150912.1 NZ_CP089882:727644-727937 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT229574 NZ_CP124495:c188009-187944 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References