Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 349208..349854 Replicon chromosome
Accession NZ_CP089882
Organism Klebsiella pneumoniae strain KP059

Toxin (Protein)


Gene name higB Uniprot ID A0A486LFK7
Locus tag LVQ69_RS01610 Protein ID WP_023301313.1
Coordinates 349208..349555 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag LVQ69_RS01615 Protein ID WP_002920557.1
Coordinates 349555..349854 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVQ69_RS01600 (LVQ69_01600) 345134..346567 + 1434 WP_002920564.1 glycogen synthase GlgA -
LVQ69_RS01605 (LVQ69_01605) 346585..349032 + 2448 WP_002920561.1 glycogen phosphorylase -
LVQ69_RS01610 (LVQ69_01610) 349208..349555 + 348 WP_023301313.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LVQ69_RS01615 (LVQ69_01615) 349555..349854 + 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
LVQ69_RS01620 (LVQ69_01620) 349917..351425 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
LVQ69_RS01625 (LVQ69_01625) 351630..351959 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
LVQ69_RS01630 (LVQ69_01630) 352010..352840 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
LVQ69_RS01635 (LVQ69_01635) 352890..353648 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13506.49 Da        Isoelectric Point: 6.2327

>T229573 WP_023301313.1 NZ_CP089882:349208-349555 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKETITMADREFSQHLTKER

Download         Length: 348 bp

>T229573 NZ_CP124494:c59072-58767 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTTCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCCCGCCTGCTGTCAGACAAAGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGTCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT229573 WP_002920557.1 NZ_CP089882:349555-349854 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT229573 NZ_CP124494:c59292-59074 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAATTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486LFK7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References