Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 733809..734584 Replicon chromosome
Accession NZ_CP089880
Organism Klebsiella pneumoniae strain KP309

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag LVQ72_RS03660 Protein ID WP_048255216.1
Coordinates 734099..734584 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag LVQ72_RS03655 Protein ID WP_004150912.1
Coordinates 733809..734102 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVQ72_RS03635 (LVQ72_03635) 729018..729620 - 603 WP_004174410.1 short chain dehydrogenase -
LVQ72_RS03640 (LVQ72_03640) 729718..730629 + 912 WP_048255220.1 LysR family transcriptional regulator -
LVQ72_RS03645 (LVQ72_03645) 730630..731778 - 1149 WP_048255218.1 PLP-dependent aspartate aminotransferase family protein -
LVQ72_RS03650 (LVQ72_03650) 731789..733165 - 1377 WP_004174417.1 pyridoxal-phosphate dependent enzyme -
LVQ72_RS03655 (LVQ72_03655) 733809..734102 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
LVQ72_RS03660 (LVQ72_03660) 734099..734584 + 486 WP_048255216.1 GNAT family N-acetyltransferase Toxin
LVQ72_RS03665 (LVQ72_03665) 735282..735875 + 594 Protein_720 hypothetical protein -
LVQ72_RS03670 (LVQ72_03670) 735972..736188 + 217 Protein_721 transposase -
LVQ72_RS03680 (LVQ72_03680) 737029..737742 - 714 WP_002916694.1 DUF554 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 735972..736124 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17594.62 Da        Isoelectric Point: 8.8818

>T229553 WP_048255216.1 NZ_CP089880:734099-734584 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVNKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

>T229553 NZ_CP124492:188058-188165 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT229553 WP_004150912.1 NZ_CP089880:733809-734102 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT229553 NZ_CP124492:c188009-187944 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References