Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 324315..324901 Replicon chromosome
Accession NZ_CP089877
Organism Klebsiella pneumoniae strain KP308

Toxin (Protein)


Gene name doc Uniprot ID A0A9J6Y968
Locus tag LVQ70_RS01510 Protein ID WP_025367836.1
Coordinates 324533..324901 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag LVQ70_RS01505 Protein ID WP_004174006.1
Coordinates 324315..324536 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVQ70_RS01485 (LVQ70_01485) 320472..321398 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
LVQ70_RS01490 (LVQ70_01490) 321395..322672 + 1278 WP_004188292.1 branched chain amino acid ABC transporter permease LivM -
LVQ70_RS01495 (LVQ70_01495) 322669..323436 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
LVQ70_RS01500 (LVQ70_01500) 323438..324151 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
LVQ70_RS01505 (LVQ70_01505) 324315..324536 + 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LVQ70_RS01510 (LVQ70_01510) 324533..324901 + 369 WP_025367836.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
LVQ70_RS01515 (LVQ70_01515) 325174..326490 + 1317 WP_004174008.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
LVQ70_RS01520 (LVQ70_01520) 326597..327484 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
LVQ70_RS01525 (LVQ70_01525) 327481..328326 + 846 WP_004145129.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
LVQ70_RS01530 (LVQ70_01530) 328328..329398 + 1071 WP_004150074.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 321395..330135 8740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13449.86 Da        Isoelectric Point: 7.2790

>T229531 WP_025367836.1 NZ_CP089877:324533-324901 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIECEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLLG

Download         Length: 369 bp

>T229531 NZ_CP124488:c13928-13794 [Escherichia coli]
ATGACGAAATATACCCTTATCGGGTTGCTTGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACAGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT229531 WP_004174006.1 NZ_CP089877:324315-324536 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT229531 NZ_CP124488:13973-14033 [Escherichia coli]
TAAAGTGCATCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References