Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 351689..352335 Replicon chromosome
Accession NZ_CP089874
Organism Klebsiella pneumoniae strain KP106

Toxin (Protein)


Gene name higB Uniprot ID A0A332YAY3
Locus tag LVQ73_RS01625 Protein ID WP_032435150.1
Coordinates 351689..352036 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A231WWU8
Locus tag LVQ73_RS01630 Protein ID WP_004174017.1
Coordinates 352036..352335 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVQ73_RS01615 (347615) 347615..349048 + 1434 WP_002920564.1 glycogen synthase GlgA -
LVQ73_RS01620 (349066) 349066..351513 + 2448 WP_002920561.1 glycogen phosphorylase -
LVQ73_RS01625 (351689) 351689..352036 + 348 WP_032435150.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LVQ73_RS01630 (352036) 352036..352335 + 300 WP_004174017.1 XRE family transcriptional regulator Antitoxin
LVQ73_RS01635 (352398) 352398..353906 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
LVQ73_RS01640 (354111) 354111..354440 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
LVQ73_RS01645 (354491) 354491..355321 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
LVQ73_RS01650 (355371) 355371..356129 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13531.52 Da        Isoelectric Point: 5.6749

>T229511 WP_032435150.1 NZ_CP089874:351689-352036 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATILILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T229511 NZ_CP124487:188541-188648 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGTTCCGGTCATTACTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10844.64 Da        Isoelectric Point: 10.1464

>AT229511 WP_004174017.1 NZ_CP089874:352036-352335 [Klebsiella pneumoniae]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQTDNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT229511 NZ_CP124487:c188484-188427 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A332YAY3

Antitoxin

Source ID Structure
AlphaFold DB A0A231WWU8

References