Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 350489..351135 Replicon chromosome
Accession NZ_CP089870
Organism Klebsiella pneumoniae strain KP037

Toxin (Protein)


Gene name higB Uniprot ID A0A332YAY3
Locus tag LVQ68_RS01615 Protein ID WP_032435150.1
Coordinates 350489..350836 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A231WWU8
Locus tag LVQ68_RS01620 Protein ID WP_004174017.1
Coordinates 350836..351135 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVQ68_RS01605 (346415) 346415..347848 + 1434 WP_002920564.1 glycogen synthase GlgA -
LVQ68_RS01610 (347866) 347866..350313 + 2448 WP_002920561.1 glycogen phosphorylase -
LVQ68_RS01615 (350489) 350489..350836 + 348 WP_032435150.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LVQ68_RS01620 (350836) 350836..351135 + 300 WP_004174017.1 XRE family transcriptional regulator Antitoxin
LVQ68_RS01625 (351198) 351198..352706 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
LVQ68_RS01630 (352911) 352911..353240 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
LVQ68_RS01635 (353291) 353291..354121 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
LVQ68_RS01640 (354171) 354171..354929 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13531.52 Da        Isoelectric Point: 5.6749

>T229490 WP_032435150.1 NZ_CP089870:350489-350836 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATILILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T229490 NZ_CP124483:245889-245996 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGTTCCGGTCATTACTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10844.64 Da        Isoelectric Point: 10.1464

>AT229490 WP_004174017.1 NZ_CP089870:350836-351135 [Klebsiella pneumoniae]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQTDNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT229490 NZ_CP124483:c245832-245775 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A332YAY3

Antitoxin

Source ID Structure
AlphaFold DB A0A231WWU8

References