Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 324300..324886 Replicon chromosome
Accession NZ_CP089870
Organism Klebsiella pneumoniae strain KP037

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag LVQ68_RS01505 Protein ID WP_002920800.1
Coordinates 324518..324886 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag LVQ68_RS01500 Protein ID WP_004174006.1
Coordinates 324300..324521 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVQ68_RS01480 (320457) 320457..321383 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
LVQ68_RS01485 (321380) 321380..322657 + 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
LVQ68_RS01490 (322654) 322654..323421 + 768 WP_032435160.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
LVQ68_RS01495 (323423) 323423..324136 + 714 WP_087652577.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
LVQ68_RS01500 (324300) 324300..324521 + 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LVQ68_RS01505 (324518) 324518..324886 + 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
LVQ68_RS01510 (325159) 325159..326475 + 1317 WP_038990613.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
LVQ68_RS01515 (326582) 326582..327469 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
LVQ68_RS01520 (327466) 327466..328311 + 846 WP_004185988.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
LVQ68_RS01525 (328313) 328313..329383 + 1071 WP_004150074.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 321380..330120 8740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T229489 WP_002920800.1 NZ_CP089870:324518-324886 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T229489 NZ_CP124483:245406-245513 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT229489 WP_004174006.1 NZ_CP089870:324300-324521 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT229489 NZ_CP124483:c245357-245292 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References