Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2401560..2402131 Replicon chromosome
Accession NZ_CP089848
Organism Paralcaligenes sp. KSB-10

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LSG25_RS10885 Protein ID WP_232740960.1
Coordinates 2401560..2401838 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag LSG25_RS10890 Protein ID WP_232740961.1
Coordinates 2401838..2402131 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSG25_RS10850 (LSG25_10850) 2397501..2398520 + 1020 WP_232740957.1 hypothetical protein -
LSG25_RS10870 (LSG25_10870) 2399390..2399728 + 339 WP_232744652.1 type II toxin-antitoxin system RelE/ParE family toxin -
LSG25_RS10875 (LSG25_10875) 2399725..2400006 + 282 WP_232740958.1 XRE family transcriptional regulator -
LSG25_RS10880 (LSG25_10880) 2400238..2401014 + 777 WP_232740959.1 hypothetical protein -
LSG25_RS10885 (LSG25_10885) 2401560..2401838 + 279 WP_232740960.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LSG25_RS10890 (LSG25_10890) 2401838..2402131 + 294 WP_232740961.1 HigA family addiction module antitoxin Antitoxin
LSG25_RS10895 (LSG25_10895) 2402351..2403247 - 897 WP_232744653.1 LysR family transcriptional regulator -
LSG25_RS10900 (LSG25_10900) 2403345..2403785 + 441 WP_232740962.1 heme-binding protein -
LSG25_RS10905 (LSG25_10905) 2403816..2404829 + 1014 WP_232740963.1 zinc-binding alcohol dehydrogenase family protein -
LSG25_RS10910 (LSG25_10910) 2405087..2405665 - 579 WP_232740964.1 NAD(P)-binding domain-containing protein -
LSG25_RS10915 (LSG25_10915) 2405739..2405825 - 87 Protein_2145 oxidoreductase -
LSG25_RS10920 (LSG25_10920) 2406006..2406953 + 948 WP_232740965.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-66)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10696.15 Da        Isoelectric Point: 8.5626

>T229476 WP_232740960.1 NZ_CP089848:2401560-2401838 [Paralcaligenes sp. KSB-10]
MIKSFRHKGLRRLFETGNASGVQVSHAKRLRLQLSALDTAQVIEDMDIPGFRLHPLKGSMKDRWSITVNGNWRITFEFED
GNAYVLDYEDYH

Download         Length: 279 bp

>T229476 NZ_CP124481:c2850652-2850550 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10572.06 Da        Isoelectric Point: 8.6604

>AT229476 WP_232740961.1 NZ_CP089848:2401838-2402131 [Paralcaligenes sp. KSB-10]
MNMHNPPHPGEFISGIYLEPNNISGRELAQALGVAASTLSRVLNGTSRVTPEMALRLSKSLGRSPESWLTMQDAYDLWLA
RQHVNLQGVGKLQFAGA

Download         Length: 294 bp

>AT229476 NZ_CP124481:2850512-2850780 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATATTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References