Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4608200..4608954 Replicon chromosome
Accession NZ_CP089794
Organism Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00814

Toxin (Protein)


Gene name higB Uniprot ID B5F003
Locus tag LUY18_RS22225 Protein ID WP_000558166.1
Coordinates 4608200..4608511 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LUY18_RS22230 Protein ID WP_001259011.1
Coordinates 4608508..4608954 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUY18_RS22195 (4603858) 4603858..4604760 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
LUY18_RS22200 (4604757) 4604757..4605392 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
LUY18_RS22205 (4605389) 4605389..4606318 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
LUY18_RS22210 (4606365) 4606365..4606655 - 291 WP_000362052.1 DNA-binding transcriptional regulator -
LUY18_RS22215 (4606656) 4606656..4606967 - 312 WP_023138876.1 hypothetical protein -
LUY18_RS22220 (4607185) 4607185..4608114 + 930 WP_001127698.1 alpha/beta hydrolase -
LUY18_RS22225 (4608200) 4608200..4608511 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin Toxin
LUY18_RS22230 (4608508) 4608508..4608954 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
LUY18_RS22235 (4608969) 4608969..4609910 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
LUY18_RS22240 (4609955) 4609955..4610392 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
LUY18_RS22245 (4610389) 4610389..4611261 - 873 WP_000921423.1 virulence factor BrkB family protein -
LUY18_RS22250 (4611255) 4611255..4611854 - 600 WP_000965695.1 glucose-1-phosphatase -
LUY18_RS22255 (4612045) 4612045..4612848 - 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
LUY18_RS22260 (4612882) 4612882..4613778 - 897 WP_001520529.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(93-146)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12432.40 Da        Isoelectric Point: 9.5334

>T229390 WP_000558166.1 NZ_CP089794:4608200-4608511 [Salmonella enterica subsp. enterica serovar Kentucky]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Download         Length: 312 bp

>T229390 NZ_CP124461:88322-88456 [Escherichia coli]
ATGACGAAATATACCCTTATCGGGTTGCTTGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACAGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTGA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16734.08 Da        Isoelectric Point: 6.6451

>AT229390 WP_001259011.1 NZ_CP089794:4608508-4608954 [Salmonella enterica subsp. enterica serovar Kentucky]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT229390 NZ_CP124461:c88277-88217 [Escherichia coli]
TAAAGTGCATCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9ME90

Antitoxin

Source ID Structure

References