Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 4608200..4608954 | Replicon | chromosome |
Accession | NZ_CP089794 | ||
Organism | Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00814 |
Toxin (Protein)
Gene name | higB | Uniprot ID | B5F003 |
Locus tag | LUY18_RS22225 | Protein ID | WP_000558166.1 |
Coordinates | 4608200..4608511 (+) | Length | 104 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | LUY18_RS22230 | Protein ID | WP_001259011.1 |
Coordinates | 4608508..4608954 (+) | Length | 149 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LUY18_RS22195 (4603858) | 4603858..4604760 | + | 903 | WP_000331361.1 | formate dehydrogenase subunit beta | - |
LUY18_RS22200 (4604757) | 4604757..4605392 | + | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
LUY18_RS22205 (4605389) | 4605389..4606318 | + | 930 | WP_000027730.1 | formate dehydrogenase accessory protein FdhE | - |
LUY18_RS22210 (4606365) | 4606365..4606655 | - | 291 | WP_000362052.1 | DNA-binding transcriptional regulator | - |
LUY18_RS22215 (4606656) | 4606656..4606967 | - | 312 | WP_023138876.1 | hypothetical protein | - |
LUY18_RS22220 (4607185) | 4607185..4608114 | + | 930 | WP_001127698.1 | alpha/beta hydrolase | - |
LUY18_RS22225 (4608200) | 4608200..4608511 | + | 312 | WP_000558166.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
LUY18_RS22230 (4608508) | 4608508..4608954 | + | 447 | WP_001259011.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
LUY18_RS22235 (4608969) | 4608969..4609910 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
LUY18_RS22240 (4609955) | 4609955..4610392 | - | 438 | WP_000560969.1 | D-aminoacyl-tRNA deacylase | - |
LUY18_RS22245 (4610389) | 4610389..4611261 | - | 873 | WP_000921423.1 | virulence factor BrkB family protein | - |
LUY18_RS22250 (4611255) | 4611255..4611854 | - | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
LUY18_RS22255 (4612045) | 4612045..4612848 | - | 804 | WP_000059693.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
LUY18_RS22260 (4612882) | 4612882..4613778 | - | 897 | WP_001520529.1 | sugar kinase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12432.40 Da Isoelectric Point: 9.5334
>T229390 WP_000558166.1 NZ_CP089794:4608200-4608511 [Salmonella enterica subsp. enterica serovar Kentucky]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
Download Length: 312 bp
>T229390 NZ_CP124461:88322-88456 [Escherichia coli]
ATGACGAAATATACCCTTATCGGGTTGCTTGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACAGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTGA
ATGACGAAATATACCCTTATCGGGTTGCTTGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACAGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTGA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16734.08 Da Isoelectric Point: 6.6451
>AT229390 WP_001259011.1 NZ_CP089794:4608508-4608954 [Salmonella enterica subsp. enterica serovar Kentucky]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
>AT229390 NZ_CP124461:c88277-88217 [Escherichia coli]
TAAAGTGCATCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TAAAGTGCATCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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