229369

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4605478..4606232 Replicon chromosome
Accession NZ_CP089792
Organism Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00816

Toxin (Protein)


Gene name higB Uniprot ID B5F003
Locus tag LUY16_RS22210 Protein ID WP_000558166.1
Coordinates 4605478..4605789 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LUY16_RS22215 Protein ID WP_001259011.1
Coordinates 4605786..4606232 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUY16_RS22180 (4601136) 4601136..4602038 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
LUY16_RS22185 (4602035) 4602035..4602670 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
LUY16_RS22190 (4602667) 4602667..4603596 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
LUY16_RS22195 (4603643) 4603643..4603933 - 291 WP_000362052.1 DNA-binding transcriptional regulator -
LUY16_RS22200 (4603934) 4603934..4604245 - 312 WP_023138876.1 hypothetical protein -
LUY16_RS22205 (4604463) 4604463..4605392 + 930 WP_001127698.1 alpha/beta hydrolase -
LUY16_RS22210 (4605478) 4605478..4605789 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin Toxin
LUY16_RS22215 (4605786) 4605786..4606232 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
LUY16_RS22220 (4606247) 4606247..4607188 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
LUY16_RS22225 (4607233) 4607233..4607670 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
LUY16_RS22230 (4607667) 4607667..4608539 - 873 WP_000921423.1 virulence factor BrkB family protein -
LUY16_RS22235 (4608533) 4608533..4609132 - 600 WP_000965695.1 glucose-1-phosphatase -
LUY16_RS22240 (4609323) 4609323..4610126 - 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
LUY16_RS22245 (4610160) 4610160..4611056 - 897 WP_001520529.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(93-146)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12432.40 Da        Isoelectric Point: 9.5334

>T229369 WP_000558166.1 NZ_CP089792:4605478-4605789 [Salmonella enterica subsp. enterica serovar Kentucky]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Download         Length: 312 bp

>T229369 NZ_CP124460:c237630-236308 [Escherichia coli]
ATGCCTAAACTAGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCAGCTGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATCCCCGAAGA
TGAAACCGTAACGTGTCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGTTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACTGCGCTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAGGGAATAACGCCAACGACGCACATTATCAAATTGCCGATTGGCGAAAT
CAGACAGCCCAATGCGACGCTCGATCTTAGCCAAAGCGTTGATAATGAGTATTACTGTTTGCTGCTGGCGAAAGAACTCG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGCCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCCGGTATCGCGCAAATTATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAGTTTCAGGTCTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGGCTCACACCATTTTACGACATCATTTCGGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTCTGGCGACAGCAAAGGTGCTGAAATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCACGATCGGTTAAGCCGAGAATACGGTATTAAGTAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16734.08 Da        Isoelectric Point: 6.6451

>AT229369 WP_001259011.1 NZ_CP089792:4605786-4606232 [Salmonella enterica subsp. enterica serovar Kentucky]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT229369 NZ_CP124460:c237896-237630 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAACGGCTGGAC
GCAGAGCGAGTTGGCGAAAAAAATCGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAATCCTGACAATACCTCGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAAGCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9ME90

Antitoxin

Source ID Structure

References