Detailed information of TA system TA229368

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4603643..4604245
• Replicon: chromosome
• Accession: NZ_CP089792
• Organism: Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00816

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A603E470
• Locus tag: LUY16_RS22200
• Protein ID: WP_023138876.1
• Coordinates: 4603934..4604245 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LUY16_RS22195
• Protein ID: WP_000362052.1
• Coordinates: 4603643..4603933 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LUY16_RS22180 (4601136)	4601136..4602038	+	903	WP_000331361.1	formate dehydrogenase subunit beta	-
LUY16_RS22185 (4602035)	4602035..4602670	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
LUY16_RS22190 (4602667)	4602667..4603596	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
LUY16_RS22195 (4603643)	4603643..4603933	-	291	WP_000362052.1	DNA-binding transcriptional regulator	Antitoxin
LUY16_RS22200 (4603934)	4603934..4604245	-	312	WP_023138876.1	hypothetical protein	Toxin
LUY16_RS22205 (4604463)	4604463..4605392	+	930	WP_001127698.1	alpha/beta hydrolase	-
LUY16_RS22210 (4605478)	4605478..4605789	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
LUY16_RS22215 (4605786)	4605786..4606232	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
LUY16_RS22220 (4606247)	4606247..4607188	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
LUY16_RS22225 (4607233)	4607233..4607670	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
LUY16_RS22230 (4607667)	4607667..4608539	-	873	WP_000921423.1	virulence factor BrkB family protein	-
LUY16_RS22235 (4608533)	4608533..4609132	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (37-74)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12356.30 Da
• Isoelectric Point: 9.4460

>T229368 WP_023138876.1 NZ_CP089792:c4604245-4603934 [Salmonella enterica subsp. enterica serovar Kentucky]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGSRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T229368 NZ_CP124456:c139890-139510 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGCAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10970.65 Da
• Isoelectric Point: 11.0303

>AT229368 WP_000362052.1 NZ_CP089792:c4603933-4603643 [Salmonella enterica subsp. enterica serovar Kentucky]
MDKVLFERLTQSMSQMNEIIEGTRKPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT229368 NZ_CP124456:c140111-139890 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAGGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Structures

Toxin

• AlphaFold DB: A0A603E470