Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 4607481..4608235 | Replicon | chromosome |
Accession | NZ_CP089791 | ||
Organism | Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00820 |
Toxin (Protein)
Gene name | higB | Uniprot ID | B5F003 |
Locus tag | LUY13_RS22230 | Protein ID | WP_000558166.1 |
Coordinates | 4607481..4607792 (+) | Length | 104 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | LUY13_RS22235 | Protein ID | WP_001259011.1 |
Coordinates | 4607789..4608235 (+) | Length | 149 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LUY13_RS22200 (4603139) | 4603139..4604041 | + | 903 | WP_000331361.1 | formate dehydrogenase subunit beta | - |
LUY13_RS22205 (4604038) | 4604038..4604673 | + | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
LUY13_RS22210 (4604670) | 4604670..4605599 | + | 930 | WP_000027730.1 | formate dehydrogenase accessory protein FdhE | - |
LUY13_RS22215 (4605646) | 4605646..4605936 | - | 291 | WP_000362052.1 | DNA-binding transcriptional regulator | - |
LUY13_RS22220 (4605937) | 4605937..4606248 | - | 312 | WP_023138876.1 | hypothetical protein | - |
LUY13_RS22225 (4606466) | 4606466..4607395 | + | 930 | WP_001127698.1 | alpha/beta hydrolase | - |
LUY13_RS22230 (4607481) | 4607481..4607792 | + | 312 | WP_000558166.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
LUY13_RS22235 (4607789) | 4607789..4608235 | + | 447 | WP_001259011.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
LUY13_RS22240 (4608250) | 4608250..4609191 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
LUY13_RS22245 (4609236) | 4609236..4609673 | - | 438 | WP_000560969.1 | D-aminoacyl-tRNA deacylase | - |
LUY13_RS22250 (4609670) | 4609670..4610542 | - | 873 | WP_000921423.1 | virulence factor BrkB family protein | - |
LUY13_RS22255 (4610536) | 4610536..4611135 | - | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
LUY13_RS22260 (4611326) | 4611326..4612129 | - | 804 | WP_000059693.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
LUY13_RS22265 (4612163) | 4612163..4613059 | - | 897 | WP_001520529.1 | sugar kinase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12432.40 Da Isoelectric Point: 9.5334
>T229348 WP_000558166.1 NZ_CP089791:4607481-4607792 [Salmonella enterica subsp. enterica serovar Kentucky]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
Download Length: 312 bp
>T229348 NZ_CP124455:717264-717548 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGATAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAATGA
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGATAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAATGA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16734.08 Da Isoelectric Point: 6.6451
>AT229348 WP_001259011.1 NZ_CP089791:4607789-4608235 [Salmonella enterica subsp. enterica serovar Kentucky]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
>AT229348 NZ_CP124455:717028-717261 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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