Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4607481..4608235 Replicon chromosome
Accession NZ_CP089791
Organism Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00820

Toxin (Protein)


Gene name higB Uniprot ID B5F003
Locus tag LUY13_RS22230 Protein ID WP_000558166.1
Coordinates 4607481..4607792 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LUY13_RS22235 Protein ID WP_001259011.1
Coordinates 4607789..4608235 (+) Length 149 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUY13_RS22200 (4603139) 4603139..4604041 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
LUY13_RS22205 (4604038) 4604038..4604673 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
LUY13_RS22210 (4604670) 4604670..4605599 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
LUY13_RS22215 (4605646) 4605646..4605936 - 291 WP_000362052.1 DNA-binding transcriptional regulator -
LUY13_RS22220 (4605937) 4605937..4606248 - 312 WP_023138876.1 hypothetical protein -
LUY13_RS22225 (4606466) 4606466..4607395 + 930 WP_001127698.1 alpha/beta hydrolase -
LUY13_RS22230 (4607481) 4607481..4607792 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin Toxin
LUY13_RS22235 (4607789) 4607789..4608235 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
LUY13_RS22240 (4608250) 4608250..4609191 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
LUY13_RS22245 (4609236) 4609236..4609673 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
LUY13_RS22250 (4609670) 4609670..4610542 - 873 WP_000921423.1 virulence factor BrkB family protein -
LUY13_RS22255 (4610536) 4610536..4611135 - 600 WP_000965695.1 glucose-1-phosphatase -
LUY13_RS22260 (4611326) 4611326..4612129 - 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
LUY13_RS22265 (4612163) 4612163..4613059 - 897 WP_001520529.1 sugar kinase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 104 a.a.        Molecular weight: 12432.40 Da        Isoelectric Point: 9.5334

>T229348 WP_000558166.1 NZ_CP089791:4607481-4607792 [Salmonella enterica subsp. enterica serovar Kentucky]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Download         Length: 312 bp

>T229348 NZ_CP124455:717264-717548 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGATAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAATGA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16734.08 Da        Isoelectric Point: 6.6451

>AT229348 WP_001259011.1 NZ_CP089791:4607789-4608235 [Salmonella enterica subsp. enterica serovar Kentucky]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT229348 NZ_CP124455:717028-717261 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0R9ME90


Antitoxin

Source ID Structure

References