Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4607121..4607723 Replicon chromosome
Accession NZ_CP089789
Organism Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00831

Toxin (Protein)


Gene name higB Uniprot ID A0A603E470
Locus tag LUY20_RS22220 Protein ID WP_023138876.1
Coordinates 4607412..4607723 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LUY20_RS22215 Protein ID WP_000362052.1
Coordinates 4607121..4607411 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUY20_RS22200 (4604614) 4604614..4605516 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
LUY20_RS22205 (4605513) 4605513..4606148 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
LUY20_RS22210 (4606145) 4606145..4607074 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
LUY20_RS22215 (4607121) 4607121..4607411 - 291 WP_000362052.1 DNA-binding transcriptional regulator Antitoxin
LUY20_RS22220 (4607412) 4607412..4607723 - 312 WP_023138876.1 hypothetical protein Toxin
LUY20_RS22225 (4607941) 4607941..4608870 + 930 WP_001127698.1 alpha/beta hydrolase -
LUY20_RS22230 (4608956) 4608956..4609267 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
LUY20_RS22235 (4609264) 4609264..4609710 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
LUY20_RS22240 (4609725) 4609725..4610666 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
LUY20_RS22245 (4610711) 4610711..4611148 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
LUY20_RS22250 (4611145) 4611145..4612017 - 873 WP_000921423.1 virulence factor BrkB family protein -
LUY20_RS22255 (4612011) 4612011..4612610 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(37-74)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12356.30 Da        Isoelectric Point: 9.4460

>T229305 WP_023138876.1 NZ_CP089789:c4607723-4607412 [Salmonella enterica subsp. enterica serovar Kentucky]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGSRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

>T229305 NZ_CP124436:c2619197-2619090 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10970.65 Da        Isoelectric Point: 11.0303

>AT229305 WP_000362052.1 NZ_CP089789:c4607411-4607121 [Salmonella enterica subsp. enterica serovar Kentucky]
MDKVLFERLTQSMSQMNEIIEGTRKPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp

>AT229305 NZ_CP124436:2619246-2619311 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A603E470

Antitoxin

Source ID Structure

References