Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 277015..277769 Replicon chromosome
Accession NZ_CP089788
Organism Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00847

Toxin (Protein)


Gene name higB Uniprot ID B5F003
Locus tag LUY19_RS01370 Protein ID WP_000558166.1
Coordinates 277458..277769 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LUY19_RS01365 Protein ID WP_001259011.1
Coordinates 277015..277461 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUY19_RS01335 (272191) 272191..273087 + 897 WP_001520529.1 sugar kinase -
LUY19_RS01340 (273121) 273121..273924 + 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
LUY19_RS01345 (274115) 274115..274714 + 600 WP_000965695.1 glucose-1-phosphatase -
LUY19_RS01350 (274708) 274708..275580 + 873 WP_000921423.1 virulence factor BrkB family protein -
LUY19_RS01355 (275577) 275577..276014 + 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
LUY19_RS01360 (276059) 276059..277000 + 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
LUY19_RS01365 (277015) 277015..277461 - 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
LUY19_RS01370 (277458) 277458..277769 - 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin Toxin
LUY19_RS01375 (277855) 277855..278784 - 930 WP_001127698.1 alpha/beta hydrolase -
LUY19_RS01380 (279002) 279002..279313 + 312 WP_023138876.1 hypothetical protein -
LUY19_RS01385 (279314) 279314..279604 + 291 WP_000362052.1 DNA-binding transcriptional regulator -
LUY19_RS01390 (279651) 279651..280580 - 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
LUY19_RS01395 (280577) 280577..281212 - 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
LUY19_RS01400 (281209) 281209..282111 - 903 WP_000331361.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(93-146)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12432.40 Da        Isoelectric Point: 9.5334

>T229265 WP_000558166.1 NZ_CP089788:c277769-277458 [Salmonella enterica subsp. enterica serovar Kentucky]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Download         Length: 312 bp

>T229265 NZ_CP124425:c59344-59210 [Escherichia coli]
ATGACGAAATATACCCTTATCGGGTTGCTTGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACAGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTGA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16734.08 Da        Isoelectric Point: 6.6451

>AT229265 WP_001259011.1 NZ_CP089788:c277461-277015 [Salmonella enterica subsp. enterica serovar Kentucky]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT229265 NZ_CP124425:59389-59449 [Escherichia coli]
TAAAGTGCATCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9ME90

Antitoxin

Source ID Structure

References