Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 277015..277769 | Replicon | chromosome |
Accession | NZ_CP089788 | ||
Organism | Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00847 |
Toxin (Protein)
Gene name | higB | Uniprot ID | B5F003 |
Locus tag | LUY19_RS01370 | Protein ID | WP_000558166.1 |
Coordinates | 277458..277769 (-) | Length | 104 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | LUY19_RS01365 | Protein ID | WP_001259011.1 |
Coordinates | 277015..277461 (-) | Length | 149 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LUY19_RS01335 (272191) | 272191..273087 | + | 897 | WP_001520529.1 | sugar kinase | - |
LUY19_RS01340 (273121) | 273121..273924 | + | 804 | WP_000059693.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
LUY19_RS01345 (274115) | 274115..274714 | + | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
LUY19_RS01350 (274708) | 274708..275580 | + | 873 | WP_000921423.1 | virulence factor BrkB family protein | - |
LUY19_RS01355 (275577) | 275577..276014 | + | 438 | WP_000560969.1 | D-aminoacyl-tRNA deacylase | - |
LUY19_RS01360 (276059) | 276059..277000 | + | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
LUY19_RS01365 (277015) | 277015..277461 | - | 447 | WP_001259011.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
LUY19_RS01370 (277458) | 277458..277769 | - | 312 | WP_000558166.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
LUY19_RS01375 (277855) | 277855..278784 | - | 930 | WP_001127698.1 | alpha/beta hydrolase | - |
LUY19_RS01380 (279002) | 279002..279313 | + | 312 | WP_023138876.1 | hypothetical protein | - |
LUY19_RS01385 (279314) | 279314..279604 | + | 291 | WP_000362052.1 | DNA-binding transcriptional regulator | - |
LUY19_RS01390 (279651) | 279651..280580 | - | 930 | WP_000027730.1 | formate dehydrogenase accessory protein FdhE | - |
LUY19_RS01395 (280577) | 280577..281212 | - | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
LUY19_RS01400 (281209) | 281209..282111 | - | 903 | WP_000331361.1 | formate dehydrogenase subunit beta | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12432.40 Da Isoelectric Point: 9.5334
>T229265 WP_000558166.1 NZ_CP089788:c277769-277458 [Salmonella enterica subsp. enterica serovar Kentucky]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
Download Length: 312 bp
>T229265 NZ_CP124425:c59344-59210 [Escherichia coli]
ATGACGAAATATACCCTTATCGGGTTGCTTGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACAGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTGA
ATGACGAAATATACCCTTATCGGGTTGCTTGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACAGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTGA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16734.08 Da Isoelectric Point: 6.6451
>AT229265 WP_001259011.1 NZ_CP089788:c277461-277015 [Salmonella enterica subsp. enterica serovar Kentucky]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
>AT229265 NZ_CP124425:59389-59449 [Escherichia coli]
TAAAGTGCATCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TAAAGTGCATCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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