Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2962436..2963084 Replicon chromosome
Accession NZ_CP089781
Organism Mycobacterium tuberculosis strain 02-R1179

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag LVJ76_RS13975 Protein ID WP_003899414.1
Coordinates 2962436..2962759 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag LVJ76_RS13980 Protein ID WP_003899415.1
Coordinates 2962839..2963084 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ76_RS13945 (LVJ76_13955) 2957759..2958757 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
LVJ76_RS13950 (LVJ76_13960) 2958771..2959235 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
LVJ76_RS13955 (LVJ76_13965) 2959223..2959474 + 252 WP_003908028.1 hypothetical protein -
LVJ76_RS13960 (LVJ76_13970) 2959645..2961084 - 1440 WP_003899411.1 phage major capsid protein -
LVJ76_RS13965 (LVJ76_13975) 2961092..2961625 - 534 WP_003899412.1 HK97 family phage prohead protease -
LVJ76_RS13970 (LVJ76_13980) 2961778..2962269 - 492 WP_003900541.1 phage terminase small subunit P27 family -
LVJ76_RS13975 (LVJ76_13985) 2962436..2962759 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
LVJ76_RS13980 (LVJ76_13990) 2962839..2963084 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
LVJ76_RS13985 (LVJ76_13995) 2963081..2964508 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
LVJ76_RS13990 (LVJ76_14000) 2964510..2964902 - 393 WP_003899417.1 DUF2742 domain-containing protein -
LVJ76_RS13995 (LVJ76_14005) 2964899..2965159 - 261 WP_014585547.1 helix-turn-helix domain-containing protein -
LVJ76_RS14000 (LVJ76_14010) 2965176..2965538 - 363 WP_003900543.1 hypothetical protein -
LVJ76_RS14005 (LVJ76_14015) 2965541..2966668 - 1128 WP_003899420.1 site-specific integrase -
LVJ76_RS14010 (LVJ76_14020) 2966813..2967040 - 228 WP_003899421.1 hypothetical protein -
LVJ76_RS14015 (LVJ76_14025) 2967037..2967426 - 390 WP_003899422.1 hypothetical protein -
LVJ76_RS14020 (LVJ76_14030) 2967332..2967604 + 273 WP_003900544.1 hypothetical protein -
LVJ76_RS14025 (LVJ76_14035) 2967703..2967936 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2957759..2966668 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T229252 WP_003899414.1 NZ_CP089781:c2962759-2962436 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T229252 NZ_CP124424:c2364935-2364408 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCATT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTCTGCGAGCGTATATCCTGTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTAACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTTGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCATTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCGACCAAATCTATAGAGCTACTTTTTACACCAGACGATTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT229252 WP_003899415.1 NZ_CP089781:c2963084-2962839 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT229252 NZ_CP124424:c2365208-2364942 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATTGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCACTGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References