229202

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 3804455..3805122 Replicon chromosome
Accession NZ_CP089780
Organism Mycobacterium tuberculosis strain M0003941-3

Toxin (Protein)


Gene name vapC Uniprot ID O50411
Locus tag LVJ75_RS17895 Protein ID WP_003417916.1
Coordinates 3804455..3804847 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8U8S7
Locus tag LVJ75_RS17900 Protein ID WP_003912214.1
Coordinates 3804847..3805122 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ75_RS17875 (LVJ75_17860) 3800302..3801291 - 990 WP_003417912.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
LVJ75_RS17880 (LVJ75_17865) 3801291..3801680 - 390 Protein_3532 polyprenyl synthetase family protein -
LVJ75_RS17885 (LVJ75_17870) 3801733..3802994 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -
LVJ75_RS17890 (LVJ75_17875) 3803036..3803701 - 666 Protein_3534 polyprenyl synthetase family protein -
LVJ75_RS17895 (LVJ75_17880) 3804455..3804847 - 393 WP_003417916.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ75_RS17900 (LVJ75_17885) 3804847..3805122 - 276 WP_003912214.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LVJ75_RS17905 (LVJ75_17890) 3805304..3806675 + 1372 Protein_3537 ISNCY family transposase -
LVJ75_RS17910 (LVJ75_17895) 3806865..3809042 + 2178 WP_016330440.1 PE family protein -
LVJ75_RS17915 (LVJ75_17900) 3809113..3809985 - 873 WP_003906098.1 3-hydroxyacyl-thioester dehydratase HtdY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside IScluster/Tn - - 3801733..3806675 4942


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14316.74 Da        Isoelectric Point: 10.7249

>T229202 WP_003417916.1 NZ_CP089780:c3804847-3804455 [Mycobacterium tuberculosis]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRHPRVSSALARAEVMRALLDKGESARKAGRRALAHLDLLRVDKRVLDLAG
GLLPFELRTLDAIHLATAQRLGVDLGRLCTYDDRMRDAAKTLGMAVIAPS

Download         Length: 393 bp

>T229202 NZ_CP124415:c2496329-2496222 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9966.35 Da        Isoelectric Point: 4.5332

>AT229202 WP_003912214.1 NZ_CP089780:c3805122-3804847 [Mycobacterium tuberculosis]
MTSVGVRALRQRASELLRRVEAGETIEITDRGRPVALLSPLPQGGPYEQLLASGEIERATLDVVDLPEPLDLDAGVELPS
VTLARLREHER

Download         Length: 276 bp

>AT229202 NZ_CP124415:2496386-2496443 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BXS8

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8U8S7

References