229191

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2972168..2972816 Replicon chromosome
Accession NZ_CP089780
Organism Mycobacterium tuberculosis strain M0003941-3

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag LVJ75_RS14015 Protein ID WP_003899414.1
Coordinates 2972168..2972491 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag LVJ75_RS14020 Protein ID WP_003899415.1
Coordinates 2972571..2972816 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ75_RS13985 (LVJ75_13970) 2967491..2968489 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
LVJ75_RS13990 (LVJ75_13975) 2968503..2968967 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
LVJ75_RS13995 (LVJ75_13980) 2968955..2969206 + 252 WP_003908028.1 hypothetical protein -
LVJ75_RS14000 (LVJ75_13985) 2969377..2970816 - 1440 WP_003901443.1 phage major capsid protein -
LVJ75_RS14005 (LVJ75_13990) 2970824..2971357 - 534 WP_003899412.1 HK97 family phage prohead protease -
LVJ75_RS14010 (LVJ75_13995) 2971510..2972001 - 492 WP_003900541.1 phage terminase small subunit P27 family -
LVJ75_RS14015 (LVJ75_14000) 2972168..2972491 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
LVJ75_RS14020 (LVJ75_14005) 2972571..2972816 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
LVJ75_RS14025 (LVJ75_14010) 2972813..2974240 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
LVJ75_RS14030 (LVJ75_14015) 2974242..2974634 - 393 WP_003899417.1 DUF2742 domain-containing protein -
LVJ75_RS14035 (LVJ75_14020) 2974631..2974891 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
LVJ75_RS14040 (LVJ75_14025) 2974908..2975270 - 363 WP_003900543.1 hypothetical protein -
LVJ75_RS14045 (LVJ75_14030) 2975273..2976400 - 1128 WP_003899420.1 site-specific integrase -
LVJ75_RS14050 (LVJ75_14035) 2976545..2976772 - 228 WP_003899421.1 hypothetical protein -
LVJ75_RS14055 (LVJ75_14040) 2976769..2977158 - 390 WP_003899422.1 hypothetical protein -
LVJ75_RS14060 (LVJ75_14045) 2977064..2977336 + 273 WP_003900544.1 hypothetical protein -
LVJ75_RS14065 (LVJ75_14050) 2977435..2977668 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2967491..2976400 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(4-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T229191 WP_003899414.1 NZ_CP089780:c2972491-2972168 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T229191 NZ_CP124411:126655-127035 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGCAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT229191 WP_003899415.1 NZ_CP089780:c2972816-2972571 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT229191 NZ_CP124411:126434-126655 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAGGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References