Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Gp49-HTH_37 |
| Location | 2189543..2190411 | Replicon | chromosome |
| Accession | NZ_CP089780 | ||
| Organism | Mycobacterium tuberculosis strain M0003941-3 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | P9WJA4 |
| Locus tag | LVJ75_RS10200 | Protein ID | WP_010886136.1 |
| Coordinates | 2189543..2189920 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | G0TLM0 |
| Locus tag | LVJ75_RS10205 | Protein ID | WP_003409886.1 |
| Coordinates | 2189962..2190411 (+) | Length | 150 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LVJ75_RS10150 (LVJ75_10150) | 2185332..2185784 | - | 453 | WP_003899095.1 | lipoprotein | - |
| LVJ75_RS10155 (LVJ75_10155) | 2185848..2186249 | + | 402 | WP_003409869.1 | hypothetical protein | - |
| LVJ75_RS10160 (LVJ75_10160) | 2186242..2186424 | - | 183 | WP_003409870.1 | hypothetical protein | - |
| LVJ75_RS10165 (LVJ75_10165) | 2186538..2186888 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| LVJ75_RS10170 (LVJ75_10170) | 2186899..2187801 | - | 903 | WP_003899097.1 | hypothetical protein | - |
| LVJ75_RS10175 (LVJ75_10175) | 2187822..2188013 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| LVJ75_RS10180 (LVJ75_10180) | 2188014..2188310 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| LVJ75_RS10185 (LVJ75_10185) | 2188550..2188765 | + | 216 | WP_003409878.1 | antitoxin | - |
| LVJ75_RS10190 (LVJ75_10190) | 2188762..2189073 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| LVJ75_RS10195 (LVJ75_10195) | 2189047..2189568 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| LVJ75_RS10200 (LVJ75_10200) | 2189543..2189920 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | Toxin |
| LVJ75_RS10205 (LVJ75_10205) | 2189962..2190411 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | Antitoxin |
| LVJ75_RS10210 (LVJ75_10210) | 2190408..2190953 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| LVJ75_RS10215 (LVJ75_10215) | 2190842..2191456 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| LVJ75_RS10220 (LVJ75_10220) | 2191505..2191801 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| LVJ75_RS10225 (LVJ75_10225) | 2191798..2192049 | - | 252 | WP_070891338.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| LVJ75_RS10230 (LVJ75_10230) | 2192036..2192530 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| LVJ75_RS10235 (LVJ75_10235) | 2192690..2193097 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| LVJ75_RS10240 (LVJ75_10240) | 2193101..2193373 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| LVJ75_RS10245 (LVJ75_10245) | 2193406..2194626 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14397.77 Da Isoelectric Point: 10.8862
>T229175 WP_010886136.1 NZ_CP089780:2189543-2189920 [Mycobacterium tuberculosis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
Download Length: 378 bp
>T229175 NZ_CP124410:2084936-2085400 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA
Antitoxin
Download Length: 150 a.a. Molecular weight: 16760.16 Da Isoelectric Point: 8.0771
>AT229175 WP_003409886.1 NZ_CP089780:2189962-2190411 [Mycobacterium tuberculosis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
Download Length: 450 bp
>AT229175 NZ_CP124410:2084601-2084936 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAT
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAT
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|