Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Gp49-HTH_37 |
| Location | 2058984..2059852 | Replicon | chromosome |
| Accession | NZ_CP089779 | ||
| Organism | Mycobacterium tuberculosis strain 01-R1134 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | P9WJA4 |
| Locus tag | LVJ74_RS09760 | Protein ID | WP_010886136.1 |
| Coordinates | 2059475..2059852 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | G0TLM0 |
| Locus tag | LVJ74_RS09755 | Protein ID | WP_003409886.1 |
| Coordinates | 2058984..2059433 (-) | Length | 150 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LVJ74_RS09715 (LVJ74_09695) | 2054769..2055989 | + | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| LVJ74_RS09720 (LVJ74_09700) | 2056022..2056294 | + | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| LVJ74_RS09725 (LVJ74_09705) | 2056298..2056705 | + | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| LVJ74_RS09730 (LVJ74_09710) | 2056865..2057359 | - | 495 | WP_003899099.1 | hypothetical protein | - |
| LVJ74_RS09735 (LVJ74_09715) | 2057346..2057597 | + | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| LVJ74_RS09740 (LVJ74_09720) | 2057594..2057890 | + | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| LVJ74_RS09745 (LVJ74_09725) | 2057939..2058553 | + | 615 | WP_003901296.1 | hypothetical protein | - |
| LVJ74_RS09750 (LVJ74_09730) | 2058442..2058987 | - | 546 | WP_003409891.1 | SecB-like chaperone | - |
| LVJ74_RS09755 (LVJ74_09735) | 2058984..2059433 | - | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | Antitoxin |
| LVJ74_RS09760 (LVJ74_09740) | 2059475..2059852 | - | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | Toxin |
| LVJ74_RS09765 (LVJ74_09745) | 2059827..2060348 | + | 522 | WP_003904745.1 | hypothetical protein | - |
| LVJ74_RS09770 (LVJ74_09750) | 2060322..2060633 | - | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| LVJ74_RS09775 (LVJ74_09755) | 2060630..2060845 | - | 216 | WP_003409878.1 | antitoxin | - |
| LVJ74_RS09780 (LVJ74_09760) | 2061085..2061381 | + | 297 | WP_003409877.1 | hypothetical protein | - |
| LVJ74_RS09785 (LVJ74_09765) | 2061382..2061573 | + | 192 | WP_003409876.1 | hypothetical protein | - |
| LVJ74_RS09790 (LVJ74_09770) | 2061594..2062496 | + | 903 | WP_003899097.1 | hypothetical protein | - |
| LVJ74_RS09795 (LVJ74_09775) | 2062507..2062857 | + | 351 | WP_003899096.1 | hypothetical protein | - |
| LVJ74_RS09800 (LVJ74_09780) | 2062971..2063153 | + | 183 | WP_003409870.1 | hypothetical protein | - |
| LVJ74_RS09805 (LVJ74_09785) | 2063146..2063547 | - | 402 | WP_003409869.1 | hypothetical protein | - |
| LVJ74_RS09810 (LVJ74_09790) | 2063611..2064063 | + | 453 | WP_003899095.1 | lipoprotein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14397.77 Da Isoelectric Point: 10.8862
>T229111 WP_010886136.1 NZ_CP089779:c2059852-2059475 [Mycobacterium tuberculosis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
Download Length: 378 bp
>T229111 NZ_CP124387:4148963-4149265 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA
Antitoxin
Download Length: 150 a.a. Molecular weight: 16760.16 Da Isoelectric Point: 8.0771
>AT229111 WP_003409886.1 NZ_CP089779:c2059433-2058984 [Mycobacterium tuberculosis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
Download Length: 450 bp
>AT229111 NZ_CP124387:4149301-4149642 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|