229095

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 1286957..1287605 Replicon chromosome
Accession NZ_CP089779
Organism Mycobacterium tuberculosis strain 01-R1134

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag LVJ74_RS06010 Protein ID WP_003899414.1
Coordinates 1287282..1287605 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag LVJ74_RS06005 Protein ID WP_003899415.1
Coordinates 1286957..1287202 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ74_RS05960 (LVJ74_05950) 1282105..1282338 - 234 WP_003413717.1 hypothetical protein -
LVJ74_RS05965 (LVJ74_05955) 1282437..1282709 - 273 WP_003900544.1 hypothetical protein -
LVJ74_RS05970 (LVJ74_05960) 1282615..1283004 + 390 WP_003899422.1 hypothetical protein -
LVJ74_RS05975 (LVJ74_05965) 1283001..1283228 + 228 WP_003899421.1 hypothetical protein -
LVJ74_RS05980 (LVJ74_05970) 1283373..1284500 + 1128 WP_003899420.1 site-specific integrase -
LVJ74_RS05985 (LVJ74_05975) 1284503..1284865 + 363 WP_003900543.1 hypothetical protein -
LVJ74_RS05990 (LVJ74_05980) 1284882..1285142 + 261 WP_003899418.1 helix-turn-helix domain-containing protein -
LVJ74_RS05995 (LVJ74_05985) 1285139..1285531 + 393 WP_003899417.1 DUF2742 domain-containing protein -
LVJ74_RS06000 (LVJ74_05990) 1285533..1286960 + 1428 WP_003899416.1 DUF3631 domain-containing protein -
LVJ74_RS06005 (LVJ74_05995) 1286957..1287202 + 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
LVJ74_RS06010 (LVJ74_06000) 1287282..1287605 + 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
LVJ74_RS06015 (LVJ74_06005) 1287772..1288263 + 492 WP_003900541.1 phage terminase small subunit P27 family -
LVJ74_RS06020 (LVJ74_06010) 1288416..1288949 + 534 WP_003899412.1 HK97 family phage prohead protease -
LVJ74_RS06025 (LVJ74_06015) 1288957..1290396 + 1440 WP_003899411.1 phage major capsid protein -
LVJ74_RS06030 (LVJ74_06020) 1290567..1290818 - 252 WP_003908028.1 hypothetical protein -
LVJ74_RS06035 (LVJ74_06025) 1290806..1291270 - 465 WP_003900539.1 ParB N-terminal domain-containing protein -
LVJ74_RS06040 (LVJ74_06030) 1291284..1292282 - 999 WP_003900538.1 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1283373..1292282 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T229095 WP_003899414.1 NZ_CP089779:1287282-1287605 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T229095 NZ_CP124387:c1713135-1712728 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT229095 WP_003899415.1 NZ_CP089779:1286957-1287202 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT229095 NZ_CP124387:c1713382-1713116 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCACCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References