Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2986401..2987049 Replicon chromosome
Accession NZ_CP089778
Organism Mycobacterium tuberculosis strain I0003758-5

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag LVJ73_RS14080 Protein ID WP_003899414.1
Coordinates 2986401..2986724 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag LVJ73_RS14085 Protein ID WP_003899415.1
Coordinates 2986804..2987049 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ73_RS14050 (LVJ73_14055) 2981724..2982722 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
LVJ73_RS14055 (LVJ73_14060) 2982736..2983200 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
LVJ73_RS14060 (LVJ73_14065) 2983188..2983439 + 252 WP_003908028.1 hypothetical protein -
LVJ73_RS14065 (LVJ73_14070) 2983610..2985049 - 1440 WP_003899411.1 phage major capsid protein -
LVJ73_RS14070 (LVJ73_14075) 2985057..2985590 - 534 WP_003899412.1 HK97 family phage prohead protease -
LVJ73_RS14075 (LVJ73_14080) 2985743..2986234 - 492 WP_003900541.1 phage terminase small subunit P27 family -
LVJ73_RS14080 (LVJ73_14085) 2986401..2986724 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
LVJ73_RS14085 (LVJ73_14090) 2986804..2987049 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
LVJ73_RS14090 (LVJ73_14095) 2987046..2988473 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
LVJ73_RS14095 (LVJ73_14100) 2988475..2988867 - 393 WP_003899417.1 DUF2742 domain-containing protein -
LVJ73_RS14100 (LVJ73_14105) 2988864..2989124 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
LVJ73_RS14105 (LVJ73_14110) 2989141..2989503 - 363 WP_003900543.1 hypothetical protein -
LVJ73_RS14110 (LVJ73_14115) 2989506..2990633 - 1128 WP_003899420.1 site-specific integrase -
LVJ73_RS14115 (LVJ73_14120) 2990778..2991005 - 228 WP_003899421.1 hypothetical protein -
LVJ73_RS14120 (LVJ73_14125) 2991002..2991391 - 390 WP_003899422.1 hypothetical protein -
LVJ73_RS14125 (LVJ73_14130) 2991297..2991569 + 273 WP_003900544.1 hypothetical protein -
LVJ73_RS14130 (LVJ73_14135) 2991668..2991901 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2981724..2990633 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T229070 WP_003899414.1 NZ_CP089778:c2986724-2986401 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T229070 NZ_CP124385:2035482-2035859 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCAGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT229070 WP_003899415.1 NZ_CP089778:c2987049-2986804 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT229070 NZ_CP124385:2035025-2035393 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCTCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCTGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGTACCATCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACCGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References