Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Gp49-HTH_37 |
| Location | 2209193..2210061 | Replicon | chromosome |
| Accession | NZ_CP089778 | ||
| Organism | Mycobacterium tuberculosis strain I0003758-5 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | P9WJA4 |
| Locus tag | LVJ73_RS10295 | Protein ID | WP_010886136.1 |
| Coordinates | 2209193..2209570 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | G0TLM0 |
| Locus tag | LVJ73_RS10300 | Protein ID | WP_003409886.1 |
| Coordinates | 2209612..2210061 (+) | Length | 150 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LVJ73_RS10245 (LVJ73_10260) | 2204982..2205434 | - | 453 | WP_003899095.1 | lipoprotein | - |
| LVJ73_RS10250 (LVJ73_10265) | 2205498..2205899 | + | 402 | WP_003409869.1 | hypothetical protein | - |
| LVJ73_RS10255 (LVJ73_10270) | 2205892..2206074 | - | 183 | WP_003409870.1 | hypothetical protein | - |
| LVJ73_RS10260 (LVJ73_10275) | 2206188..2206538 | - | 351 | WP_003899096.1 | hypothetical protein | - |
| LVJ73_RS10265 (LVJ73_10280) | 2206549..2207451 | - | 903 | WP_003899097.1 | hypothetical protein | - |
| LVJ73_RS10270 (LVJ73_10285) | 2207472..2207663 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| LVJ73_RS10275 (LVJ73_10290) | 2207664..2207960 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| LVJ73_RS10280 (LVJ73_10295) | 2208200..2208415 | + | 216 | WP_003409878.1 | antitoxin | - |
| LVJ73_RS10285 (LVJ73_10300) | 2208412..2208723 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| LVJ73_RS10290 (LVJ73_10305) | 2208697..2209218 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| LVJ73_RS10295 (LVJ73_10310) | 2209193..2209570 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | Toxin |
| LVJ73_RS10300 (LVJ73_10315) | 2209612..2210061 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | Antitoxin |
| LVJ73_RS10305 (LVJ73_10320) | 2210058..2210603 | + | 546 | WP_003899098.1 | SecB-like chaperone | - |
| LVJ73_RS10310 (LVJ73_10325) | 2210492..2211106 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| LVJ73_RS10315 (LVJ73_10330) | 2211155..2211451 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| LVJ73_RS10320 (LVJ73_10335) | 2211448..2211699 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| LVJ73_RS10325 (LVJ73_10340) | 2211686..2212180 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| LVJ73_RS10330 (LVJ73_10345) | 2212340..2212747 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| LVJ73_RS10335 (LVJ73_10350) | 2212751..2213023 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| LVJ73_RS10340 (LVJ73_10355) | 2213056..2214276 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14397.77 Da Isoelectric Point: 10.8862
>T229055 WP_010886136.1 NZ_CP089778:2209193-2209570 [Mycobacterium tuberculosis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
Download Length: 378 bp
>T229055 NZ_CP124374:c4658653-4658546 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
Antitoxin
Download Length: 150 a.a. Molecular weight: 16760.16 Da Isoelectric Point: 8.0771
>AT229055 WP_003409886.1 NZ_CP089778:2209612-2210061 [Mycobacterium tuberculosis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
Download Length: 450 bp
>AT229055 NZ_CP124374:4658702-4658767 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|