Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2992448..2993096 Replicon chromosome
Accession NZ_CP089777
Organism Mycobacterium tuberculosis strain I0003270-1

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag LVJ72_RS14140 Protein ID WP_003899414.1
Coordinates 2992448..2992771 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag LVJ72_RS14145 Protein ID WP_003899415.1
Coordinates 2992851..2993096 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ72_RS14110 (LVJ72_14110) 2987771..2988769 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
LVJ72_RS14115 (LVJ72_14115) 2988783..2989247 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
LVJ72_RS14120 (LVJ72_14120) 2989235..2989486 + 252 WP_003908028.1 hypothetical protein -
LVJ72_RS14125 (LVJ72_14125) 2989657..2991096 - 1440 WP_003899411.1 phage major capsid protein -
LVJ72_RS14130 (LVJ72_14130) 2991104..2991637 - 534 WP_003899412.1 HK97 family phage prohead protease -
LVJ72_RS14135 (LVJ72_14135) 2991790..2992281 - 492 WP_003900541.1 phage terminase small subunit P27 family -
LVJ72_RS14140 (LVJ72_14140) 2992448..2992771 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
LVJ72_RS14145 (LVJ72_14145) 2992851..2993096 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
LVJ72_RS14150 (LVJ72_14150) 2993093..2994520 - 1428 WP_031664026.1 DUF3631 domain-containing protein -
LVJ72_RS14155 (LVJ72_14155) 2994522..2994914 - 393 WP_003899417.1 DUF2742 domain-containing protein -
LVJ72_RS14160 (LVJ72_14160) 2994911..2995171 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
LVJ72_RS14165 (LVJ72_14165) 2995188..2995550 - 363 WP_003900543.1 hypothetical protein -
LVJ72_RS14170 (LVJ72_14170) 2995553..2996680 - 1128 WP_003899420.1 site-specific integrase -
LVJ72_RS14175 (LVJ72_14175) 2996825..2997052 - 228 WP_003899421.1 hypothetical protein -
LVJ72_RS14180 (LVJ72_14180) 2997049..2997438 - 390 WP_003899422.1 hypothetical protein -
LVJ72_RS14185 (LVJ72_14185) 2997344..2997616 + 273 WP_003900544.1 hypothetical protein -
LVJ72_RS14190 (LVJ72_14190) 2997715..2997948 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2987771..2996680 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T229010 WP_003899414.1 NZ_CP089777:c2992771-2992448 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T229010 NZ_CP124372:84067-84321 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAGCAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAACTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCTTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT229010 WP_003899415.1 NZ_CP089777:c2993096-2992851 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT229010 NZ_CP124372:83819-84070 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGACAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References