Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2967262..2967910 Replicon chromosome
Accession NZ_CP089776
Organism Mycobacterium tuberculosis strain 02-R1896

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag LVJ71_RS14015 Protein ID WP_003899414.1
Coordinates 2967262..2967585 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag LVJ71_RS14020 Protein ID WP_003899415.1
Coordinates 2967665..2967910 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ71_RS13985 (LVJ71_13985) 2962585..2963583 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
LVJ71_RS13990 (LVJ71_13990) 2963597..2964061 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
LVJ71_RS13995 (LVJ71_13995) 2964049..2964300 + 252 WP_003908028.1 hypothetical protein -
LVJ71_RS14000 (LVJ71_14000) 2964471..2965910 - 1440 WP_003899411.1 phage major capsid protein -
LVJ71_RS14005 (LVJ71_14005) 2965918..2966451 - 534 WP_003899412.1 HK97 family phage prohead protease -
LVJ71_RS14010 (LVJ71_14010) 2966604..2967095 - 492 WP_003900541.1 phage terminase small subunit P27 family -
LVJ71_RS14015 (LVJ71_14015) 2967262..2967585 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
LVJ71_RS14020 (LVJ71_14020) 2967665..2967910 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
LVJ71_RS14025 (LVJ71_14025) 2967907..2969334 - 1428 WP_003912825.1 DUF3631 domain-containing protein -
LVJ71_RS14030 (LVJ71_14030) 2969336..2969728 - 393 WP_003899417.1 DUF2742 domain-containing protein -
LVJ71_RS14035 (LVJ71_14035) 2969725..2969985 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
LVJ71_RS14040 (LVJ71_14040) 2970002..2970364 - 363 WP_003900543.1 hypothetical protein -
LVJ71_RS14045 (LVJ71_14045) 2970367..2971494 - 1128 WP_003899420.1 site-specific integrase -
LVJ71_RS14050 (LVJ71_14050) 2971639..2971866 - 228 WP_003899421.1 hypothetical protein -
LVJ71_RS14055 (LVJ71_14055) 2971863..2972252 - 390 WP_003899422.1 hypothetical protein -
LVJ71_RS14060 (LVJ71_14060) 2972158..2972430 + 273 WP_003900544.1 hypothetical protein -
LVJ71_RS14065 (LVJ71_14065) 2972529..2972762 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2962585..2971494 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T228950 WP_003899414.1 NZ_CP089776:c2967585-2967262 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T228950 NZ_CP124357:3627174-3627392 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGTCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCTGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT228950 WP_003899415.1 NZ_CP089776:c2967910-2967665 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT228950 NZ_CP124357:3626774-3627148 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References