Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2975740..2976388 Replicon chromosome
Accession NZ_CP089775
Organism Mycobacterium tuberculosis strain 02-R1708

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag LVJ70_RS14020 Protein ID WP_003899414.1
Coordinates 2975740..2976063 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag LVJ70_RS14025 Protein ID WP_003899415.1
Coordinates 2976143..2976388 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ70_RS13990 (LVJ70_13990) 2971063..2972061 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
LVJ70_RS13995 (LVJ70_13995) 2972075..2972539 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
LVJ70_RS14000 (LVJ70_14000) 2972527..2972778 + 252 WP_003908028.1 hypothetical protein -
LVJ70_RS14005 (LVJ70_14005) 2972949..2974388 - 1440 WP_003899411.1 phage major capsid protein -
LVJ70_RS14010 (LVJ70_14010) 2974396..2974929 - 534 WP_003899412.1 HK97 family phage prohead protease -
LVJ70_RS14015 (LVJ70_14015) 2975082..2975573 - 492 WP_003900541.1 phage terminase small subunit P27 family -
LVJ70_RS14020 (LVJ70_14020) 2975740..2976063 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
LVJ70_RS14025 (LVJ70_14025) 2976143..2976388 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
LVJ70_RS14030 (LVJ70_14030) 2976385..2977812 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
LVJ70_RS14035 (LVJ70_14035) 2977814..2978206 - 393 WP_003899417.1 DUF2742 domain-containing protein -
LVJ70_RS14040 (LVJ70_14040) 2978203..2978463 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
LVJ70_RS14045 (LVJ70_14045) 2978480..2978842 - 363 WP_003900543.1 hypothetical protein -
LVJ70_RS14050 (LVJ70_14050) 2978845..2979972 - 1128 WP_003899420.1 site-specific integrase -
LVJ70_RS14055 (LVJ70_14055) 2980117..2980344 - 228 WP_003899421.1 hypothetical protein -
LVJ70_RS14060 (LVJ70_14060) 2980341..2980730 - 390 WP_003899422.1 hypothetical protein -
LVJ70_RS14065 (LVJ70_14065) 2980636..2980908 + 273 WP_003900544.1 hypothetical protein -
LVJ70_RS14070 (LVJ70_14070) 2981007..2981240 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2971063..2979972 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T228889 WP_003899414.1 NZ_CP089775:c2976063-2975740 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T228889 NZ_CP124353:2035489-2035866 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCAGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT228889 WP_003899415.1 NZ_CP089775:c2976388-2976143 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT228889 NZ_CP124353:2035032-2035400 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCTCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCTGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGTACCATCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACCGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References