Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Gp49-HTH_37
Location 1099420..1099945 Replicon chromosome
Accession NC_010718
Organism Natranaerobius thermophilus JW/NM-WN-LF

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NTHER_RS05270 Protein ID WP_202943886.1
Coordinates 1099679..1099945 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NTHER_RS05265 Protein ID WP_012447492.1
Coordinates 1099420..1099689 (-) Length 90 a.a.

Genomic Context

NTHER_RS05240NTHER_RS05255NTHER_RS05260NTHER_RS05280NTHER_RS05285NTHER_RS05290NTHER_RS05295NTHER_RS05300NTHER_RS05305NTHER_RS05235NTHER_RS05245NTHER_RS05250NTHER_RS05265NTHER_RS05270NTHER_RS05275
Location: 1096369..1097220 (852 bp)
Type: Others
Protein ID: WP_012447487.1
Location: 1098512..1098757 (246 bp)
Type: Others
Protein ID: WP_041366924.1
Location: 1098760..1099146 (387 bp)
Type: Others
Protein ID: WP_012447491.1
Location: 1102010..1102258 (249 bp)
Type: Others
Protein ID: WP_012447496.1
Location: 1102561..1102851 (291 bp)
Type: Others
Protein ID: WP_012447497.1
Location: 1102844..1103176 (333 bp)
Type: Others
Protein ID: WP_012447498.1
Location: 1103571..1103828 (258 bp)
Type: Others
Protein ID: WP_012447499.1
Location: 1104179..1104427 (249 bp)
Type: Others
Protein ID: WP_012447501.1
Location: 1104424..1104804 (381 bp)
Type: Others
Protein ID: WP_012447502.1
Location: 1095353..1095859 (507 bp)
Type: Others
Protein ID: WP_012447486.1
Location: 1097458..1097853 (396 bp)
Type: Others
Protein ID: WP_012447488.1
Location: 1097825..1098160 (336 bp)
Type: Others
Protein ID: WP_012447489.1
Location: 1099420..1099689 (270 bp)
Type: Antitoxin
Protein ID: WP_012447492.1
Location: 1099679..1099945 (267 bp)
Type: Toxin
Protein ID: WP_202943886.1
Location: 1100262..1101470 (1209 bp)
Type: Others
Protein ID: WP_012447495.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NTHER_RS052351095353..1095859-507WP_012447486.1RNA polymerase sigma factor-
NTHER_RS052401096369..1097220+852WP_012447487.1tyrosine-type recombinase/integrase-
NTHER_RS052451097458..1097853-396WP_012447488.1HEPN domain-containing protein-
NTHER_RS052501097825..1098160-336WP_012447489.1nucleotidyltransferase domain-containing protein-
NTHER_RS052551098512..1098757+246WP_041366924.1hypothetical protein-
NTHER_RS052601098760..1099146+387WP_012447491.1retropepsin-like domain-containing protein-
NTHER_RS052651099420..1099689-270WP_012447492.1helix-turn-helix transcriptional regulatorAntitoxin
NTHER_RS052701099679..1099945-267WP_202943886.1type II toxin-antitoxin system RelE/ParE family toxinToxin
NTHER_RS052751100262..1101470-1209WP_012447495.1IS110 family transposase-
NTHER_RS052801102010..1102258+249WP_012447496.1hypothetical protein-
NTHER_RS052851102561..1102851+291WP_012447497.1nucleotidyltransferase domain-containing protein-
NTHER_RS052901102844..1103176+333WP_012447498.1DUF86 domain-containing protein-
NTHER_RS052951103571..1103828+258WP_012447499.1hypothetical protein-
NTHER_RS053001104179..1104427+249WP_012447501.1hypothetical protein-
NTHER_RS053051104424..1104804+381WP_012447502.1retropepsin-like domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(1-77)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10615.44 Da        Isoelectric Point: 10.3352

>T22886 WP_202943886.1 NC_010718:c1099945-1099679 [Natranaerobius thermophilus JW/NM-WN-LF]
ILREIDLLEEFGLSLGMPHIRKIKNTELWELRIKHSSNIFRILFKDYNNTFVLLHGFQKKDNKTPKKDLNMALKRLKKYL
ERGDNYEP

Download         Length: 267 bp

>T22886 NC_010718:c1099945-1099679 [Natranaerobius thermophilus JW/NM-WN-LF]
ATATTACGAGAAATTGATCTTCTTGAAGAATTTGGACTTTCTCTAGGGATGCCACATATTCGTAAAATTAAAAATACAGA
ACTTTGGGAATTAAGGATCAAACATAGTTCTAACATATTTCGAATACTTTTCAAAGATTATAATAATACCTTTGTTTTAC
TCCACGGTTTTCAAAAGAAAGATAACAAAACCCCTAAAAAAGATTTGAATATGGCTTTAAAAAGGTTAAAAAAGTATCTT
GAAAGAGGTGATAATTATGAACCATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10519.21 Da        Isoelectric Point: 10.0091

>AT22886 WP_012447492.1 NC_010718:c1099689-1099420 [Natranaerobius thermophilus JW/NM-WN-LF]
MNHKKVKEKLFNNPNVKKEYDNLEVLYDIKRQVIKLRKEKGLSQKELAEKIGTKQSAISRLENESYNPSIELLYKIAKAC
DRDLHIKFD

Download         Length: 270 bp

>AT22886 NC_010718:c1099689-1099420 [Natranaerobius thermophilus JW/NM-WN-LF]
ATGAACCATAAGAAAGTTAAAGAAAAACTATTTAACAACCCTAATGTTAAAAAAGAATATGATAACTTAGAAGTCCTTTA
TGATATCAAACGACAAGTTATTAAGCTTCGCAAGGAAAAAGGTTTAAGTCAAAAAGAATTAGCTGAAAAAATAGGAACAA
AACAATCTGCAATCTCCCGATTAGAAAACGAAAGCTACAATCCAAGTATAGAGCTTTTATATAAAATAGCCAAAGCTTGC
GACAGAGATCTTCATATTAAATTTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References