Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2971233..2971881 Replicon chromosome
Accession NZ_CP089774
Organism Mycobacterium tuberculosis strain 02-R0894

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag LVJ69_RS14025 Protein ID WP_003899414.1
Coordinates 2971233..2971556 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag LVJ69_RS14030 Protein ID WP_003899415.1
Coordinates 2971636..2971881 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ69_RS13995 (LVJ69_13995) 2966556..2967554 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
LVJ69_RS14000 (LVJ69_14000) 2967568..2968032 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
LVJ69_RS14005 (LVJ69_14005) 2968020..2968271 + 252 WP_003908028.1 hypothetical protein -
LVJ69_RS14010 (LVJ69_14010) 2968442..2969881 - 1440 WP_003899411.1 phage major capsid protein -
LVJ69_RS14015 (LVJ69_14015) 2969889..2970422 - 534 WP_003899412.1 HK97 family phage prohead protease -
LVJ69_RS14020 (LVJ69_14020) 2970575..2971066 - 492 WP_003900541.1 phage terminase small subunit P27 family -
LVJ69_RS14025 (LVJ69_14025) 2971233..2971556 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
LVJ69_RS14030 (LVJ69_14030) 2971636..2971881 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
LVJ69_RS14035 (LVJ69_14035) 2971878..2973305 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
LVJ69_RS14040 (LVJ69_14040) 2973307..2973699 - 393 WP_003899417.1 DUF2742 domain-containing protein -
LVJ69_RS14045 (LVJ69_14045) 2973696..2973956 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
LVJ69_RS14050 (LVJ69_14050) 2973973..2974335 - 363 WP_003900543.1 hypothetical protein -
LVJ69_RS14055 (LVJ69_14055) 2974338..2975465 - 1128 WP_003899420.1 site-specific integrase -
LVJ69_RS14060 (LVJ69_14060) 2975610..2975837 - 228 WP_003899421.1 hypothetical protein -
LVJ69_RS14065 (LVJ69_14065) 2975834..2976223 - 390 WP_003899422.1 hypothetical protein -
LVJ69_RS14070 (LVJ69_14070) 2976129..2976401 + 273 WP_003900544.1 hypothetical protein -
LVJ69_RS14075 (LVJ69_14075) 2976500..2976733 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2966556..2975465 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T228828 WP_003899414.1 NZ_CP089774:c2971556-2971233 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T228828 NZ_CP124347:4537258-4537635 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACCCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAACTACAGAACGGTAAATGACATTACCCTGGGTAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT228828 WP_003899415.1 NZ_CP089774:c2971881-2971636 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT228828 NZ_CP124347:4536800-4537168 [Escherichia coli]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGATACCCTCGGCAGCTG
TGGTTGCGTTTATCTGGCTGTTTATCCGACACCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References