Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | unclassified/- |
Location | 2971233..2971881 | Replicon | chromosome |
Accession | NZ_CP089774 | ||
Organism | Mycobacterium tuberculosis strain 02-R0894 |
Toxin (Protein)
Gene name | novel[antitoxin] | Uniprot ID | P9WJ12 |
Locus tag | LVJ69_RS14025 | Protein ID | WP_003899414.1 |
Coordinates | 2971233..2971556 (-) | Length | 108 a.a. |
Antitoxin (Protein)
Gene name | novel[toxin] | Uniprot ID | P9WJ10 |
Locus tag | LVJ69_RS14030 | Protein ID | WP_003899415.1 |
Coordinates | 2971636..2971881 (-) | Length | 82 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LVJ69_RS13995 (LVJ69_13995) | 2966556..2967554 | + | 999 | WP_003900538.1 | tyrosine-type recombinase/integrase | - |
LVJ69_RS14000 (LVJ69_14000) | 2967568..2968032 | + | 465 | WP_003900539.1 | ParB N-terminal domain-containing protein | - |
LVJ69_RS14005 (LVJ69_14005) | 2968020..2968271 | + | 252 | WP_003908028.1 | hypothetical protein | - |
LVJ69_RS14010 (LVJ69_14010) | 2968442..2969881 | - | 1440 | WP_003899411.1 | phage major capsid protein | - |
LVJ69_RS14015 (LVJ69_14015) | 2969889..2970422 | - | 534 | WP_003899412.1 | HK97 family phage prohead protease | - |
LVJ69_RS14020 (LVJ69_14020) | 2970575..2971066 | - | 492 | WP_003900541.1 | phage terminase small subunit P27 family | - |
LVJ69_RS14025 (LVJ69_14025) | 2971233..2971556 | - | 324 | WP_003899414.1 | type II toxin-antitoxin system toxin | Toxin |
LVJ69_RS14030 (LVJ69_14030) | 2971636..2971881 | - | 246 | WP_003899415.1 | type II toxin-antitoxin system antitoxin | Antitoxin |
LVJ69_RS14035 (LVJ69_14035) | 2971878..2973305 | - | 1428 | WP_003899416.1 | DUF3631 domain-containing protein | - |
LVJ69_RS14040 (LVJ69_14040) | 2973307..2973699 | - | 393 | WP_003899417.1 | DUF2742 domain-containing protein | - |
LVJ69_RS14045 (LVJ69_14045) | 2973696..2973956 | - | 261 | WP_003899418.1 | helix-turn-helix domain-containing protein | - |
LVJ69_RS14050 (LVJ69_14050) | 2973973..2974335 | - | 363 | WP_003900543.1 | hypothetical protein | - |
LVJ69_RS14055 (LVJ69_14055) | 2974338..2975465 | - | 1128 | WP_003899420.1 | site-specific integrase | - |
LVJ69_RS14060 (LVJ69_14060) | 2975610..2975837 | - | 228 | WP_003899421.1 | hypothetical protein | - |
LVJ69_RS14065 (LVJ69_14065) | 2975834..2976223 | - | 390 | WP_003899422.1 | hypothetical protein | - |
LVJ69_RS14070 (LVJ69_14070) | 2976129..2976401 | + | 273 | WP_003900544.1 | hypothetical protein | - |
LVJ69_RS14075 (LVJ69_14075) | 2976500..2976733 | + | 234 | WP_003413717.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Prophage | - | - | 2966556..2975465 | 8909 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 108 a.a. Molecular weight: 12359.82 Da Isoelectric Point: 8.6717
>T228828 WP_003899414.1 NZ_CP089774:c2971556-2971233 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ
Download Length: 324 bp
>T228828 NZ_CP124347:4537258-4537635 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACCCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAACTACAGAACGGTAAATGACATTACCCTGGGTAAGCATCCGGAGGCGAAACAATGA
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACCCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAACTACAGAACGGTAAATGACATTACCCTGGGTAAGCATCCGGAGGCGAAACAATGA
Antitoxin
Download Length: 82 a.a. Molecular weight: 7697.71 Da Isoelectric Point: 4.8565
>AT228828 WP_003899415.1 NZ_CP089774:c2971881-2971636 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P
Download Length: 246 bp
>AT228828 NZ_CP124347:4536800-4537168 [Escherichia coli]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGATACCCTCGGCAGCTG
TGGTTGCGTTTATCTGGCTGTTTATCCGACACCCGAAACGAAAAAGTAA
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGATACCCTCGGCAGCTG
TGGTTGCGTTTATCTGGCTGTTTATCCGACACCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A045IHC4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A806JR81 |