Detailed information of TA system TA022878

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ(toxin)
• Location: 896499..897087
• Replicon: chromosome
• Accession: NC_010698
• Organism: Helicobacter pylori Shi470

Toxin (Protein)

• Gene name: TfiT
• Uniprot ID: M3P300
• Locus tag: HPSH_RS04315
• Protein ID: WP_000921941.1
• Coordinates: 896806..897087 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: TfiA
• Uniprot ID: -
• Locus tag: HPSH_RS04310
• Protein ID: WP_000065282.1
• Coordinates: 896499..896813 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPSH_RS04290	892053..892709	+	657	WP_000587369.1	ParA family protein	-
HPSH_RS04295	892794..893063	+	270	WP_000394632.1	hypothetical protein	-
HPSH_RS04300	893095..894273	+	1179	WP_000665502.1	hypothetical protein	-
HPSH_RS04305	894298..896205	-	1908	WP_001162711.1	relaxase/mobilization nuclease domain-containing protein	-
HPSH_RS04310	896499..896813	+	315	WP_000065282.1	hypothetical protein	Antitoxin
HPSH_RS04315	896806..897087	+	282	WP_000921941.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
HPSH_RS04320	897362..899089	-	1728	WP_001208196.1	type IV secretory system conjugative DNA transfer family protein	-
HPSH_RS04325	899090..899647	-	558	WP_001167785.1	hypothetical protein	-
HPSH_RS04330	899648..899938	-	291	WP_000159821.1	hypothetical protein	-
HPSH_RS04335	899935..900390	-	456	WP_000795438.1	hypothetical protein	-
HPSH_RS04340	900387..901328	-	942	WP_000625128.1	Flp pilus assembly complex ATPase component TadA	-
HPSH_RS04345	901328..901627	-	300	WP_000660135.1	hypothetical protein	-
HPSH_RS04350	901624..901887	-	264	WP_000564645.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	sabA/hopP / sabA/hopP / hopH / flgR / fliP / wbpB / futB / hopH / flaA / cheV3 / fliN / cagA / virB2/cagC / cagD / virB4/cagE / cagF / cagG / cagH / cagI / virB5/cagL / cagN / cagM / cagP / cagA / virB2/cagC / cagQ / cagS / virB7/cagT / cagU / virB8/cagV / virB6/cagW / virB9/cagX / virB10/cagY / cagZ / virB11 / virD4 / virB1 / cag3 / cag1 / cds6	600170..910748	310578

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-92)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10891.80 Da
• Isoelectric Point: 9.5726

>T22878 WP_000921941.1 NC_010698:896806-897087 [Helicobacter pylori Shi470]
MLKVRTKKDFLKDFNKHILSGRITESDVTSVVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK

Nucleotide

• Length: 282 bp

>T22878 NC_010698:896806-897087 [Helicobacter pylori Shi470]
ATGCTTAAAGTCAGAACTAAGAAAGATTTTCTTAAAGACTTTAATAAGCATATCTTATCCGGGCGTATTACAGAAAGCGA
TGTTACAAGCGTTGTTGATTGCCTCAAAGAGCAAAAACCACTCCAACAAAAGTATTGCGACCATGCCTTGAGCGGTAATC
TTAAAGGGTTGAGAGAATGCCATGTCAAGCCAAACTTGTTATTGATTTATGAAATCAAAAAACAAGAAAACGAACTTGTT
TTATTGCGTCTAGACACTCATAGCGAGCTATTTAAAAAGTGA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 12126.64 Da
• Isoelectric Point: 5.2248

>AT22878 WP_000065282.1 NC_010698:896499-896813 [Helicobacter pylori Shi470]
MSNIITDYSQYNEKQLHNFLNAIEKQLLKAEGDKKKAIKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTIASKDNPE
CDVSFGDFNDFLQIAKQERERQDA

Nucleotide

• Length: 315 bp

>AT22878 NC_010698:896499-896813 [Helicobacter pylori Shi470]
ATGTCAAATATTATTACAGATTACTCGCAATACAATGAAAAACAACTGCACAATTTCTTAAACGCCATTGAAAAACAATT
GCTTAAGGCAGAAGGGGATAAAAAAAAGGCGATAAAAAAAATCCAAGAGTGTGAATTGCAAGAACAAATGATCAGACAAG
TTTTAGCCCAAAAACATTCTCAAGAAAAAGAACCCACACAAAGTTTGTTAAATACGATCGCCTCAAAAGATAACCCAGAA
TGCGATGTTTCGTTTGGAGATTTCAATGATTTTTTACAAATAGCAAAACAAGAAAGAGAAAGGCAAGATGCTTAA

Structures

Toxin

• AlphaFold DB: M3P300