Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | unclassified/- |
Location | 2978016..2978664 | Replicon | chromosome |
Accession | NZ_CP089773 | ||
Organism | Mycobacterium tuberculosis strain 01-R1430 |
Toxin (Protein)
Gene name | novel[antitoxin] | Uniprot ID | P9WJ12 |
Locus tag | LVJ68_RS14085 | Protein ID | WP_003899414.1 |
Coordinates | 2978016..2978339 (-) | Length | 108 a.a. |
Antitoxin (Protein)
Gene name | novel[toxin] | Uniprot ID | P9WJ10 |
Locus tag | LVJ68_RS14090 | Protein ID | WP_003899415.1 |
Coordinates | 2978419..2978664 (-) | Length | 82 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LVJ68_RS14055 (LVJ68_14055) | 2973339..2974337 | + | 999 | WP_003900538.1 | tyrosine-type recombinase/integrase | - |
LVJ68_RS14060 (LVJ68_14060) | 2974351..2974815 | + | 465 | WP_003900539.1 | ParB N-terminal domain-containing protein | - |
LVJ68_RS14065 (LVJ68_14065) | 2974803..2975054 | + | 252 | WP_003908028.1 | hypothetical protein | - |
LVJ68_RS14070 (LVJ68_14070) | 2975225..2976664 | - | 1440 | WP_003899411.1 | phage major capsid protein | - |
LVJ68_RS14075 (LVJ68_14075) | 2976672..2977205 | - | 534 | WP_003899412.1 | HK97 family phage prohead protease | - |
LVJ68_RS14080 (LVJ68_14080) | 2977358..2977849 | - | 492 | WP_003900541.1 | phage terminase small subunit P27 family | - |
LVJ68_RS14085 (LVJ68_14085) | 2978016..2978339 | - | 324 | WP_003899414.1 | type II toxin-antitoxin system toxin | Toxin |
LVJ68_RS14090 (LVJ68_14090) | 2978419..2978664 | - | 246 | WP_003899415.1 | type II toxin-antitoxin system antitoxin | Antitoxin |
LVJ68_RS14095 (LVJ68_14095) | 2978661..2980088 | - | 1428 | WP_070892804.1 | DUF3631 domain-containing protein | - |
LVJ68_RS14100 (LVJ68_14100) | 2980090..2980482 | - | 393 | WP_003899417.1 | DUF2742 domain-containing protein | - |
LVJ68_RS14105 (LVJ68_14105) | 2980479..2980739 | - | 261 | WP_003899418.1 | helix-turn-helix domain-containing protein | - |
LVJ68_RS14110 (LVJ68_14110) | 2980756..2981118 | - | 363 | WP_003900543.1 | hypothetical protein | - |
LVJ68_RS14115 (LVJ68_14115) | 2981121..2982248 | - | 1128 | WP_003899420.1 | site-specific integrase | - |
LVJ68_RS14120 (LVJ68_14120) | 2982393..2982620 | - | 228 | WP_003899421.1 | hypothetical protein | - |
LVJ68_RS14125 (LVJ68_14125) | 2982617..2983006 | - | 390 | WP_003899422.1 | hypothetical protein | - |
LVJ68_RS14130 (LVJ68_14130) | 2982912..2983184 | + | 273 | WP_003900544.1 | hypothetical protein | - |
LVJ68_RS14135 (LVJ68_14135) | 2983283..2983516 | + | 234 | WP_003413717.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Prophage | - | - | 2973339..2982248 | 8909 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 108 a.a. Molecular weight: 12359.82 Da Isoelectric Point: 8.6717
>T228767 WP_003899414.1 NZ_CP089773:c2978339-2978016 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ
Download Length: 324 bp
>T228767 NZ_CP124343:c827241-826864 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCAACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAAAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCAACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAAAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA
Antitoxin
Download Length: 82 a.a. Molecular weight: 7697.71 Da Isoelectric Point: 4.8565
>AT228767 WP_003899415.1 NZ_CP089773:c2978664-2978419 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P
Download Length: 246 bp
>AT228767 NZ_CP124343:c827698-827318 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGGGGCCGGT
TCAACAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGGTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGGGGCCGGT
TCAACAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGGTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A045IHC4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A806JR81 |