Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2978016..2978664 Replicon chromosome
Accession NZ_CP089773
Organism Mycobacterium tuberculosis strain 01-R1430

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag LVJ68_RS14085 Protein ID WP_003899414.1
Coordinates 2978016..2978339 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag LVJ68_RS14090 Protein ID WP_003899415.1
Coordinates 2978419..2978664 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ68_RS14055 (LVJ68_14055) 2973339..2974337 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
LVJ68_RS14060 (LVJ68_14060) 2974351..2974815 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
LVJ68_RS14065 (LVJ68_14065) 2974803..2975054 + 252 WP_003908028.1 hypothetical protein -
LVJ68_RS14070 (LVJ68_14070) 2975225..2976664 - 1440 WP_003899411.1 phage major capsid protein -
LVJ68_RS14075 (LVJ68_14075) 2976672..2977205 - 534 WP_003899412.1 HK97 family phage prohead protease -
LVJ68_RS14080 (LVJ68_14080) 2977358..2977849 - 492 WP_003900541.1 phage terminase small subunit P27 family -
LVJ68_RS14085 (LVJ68_14085) 2978016..2978339 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
LVJ68_RS14090 (LVJ68_14090) 2978419..2978664 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
LVJ68_RS14095 (LVJ68_14095) 2978661..2980088 - 1428 WP_070892804.1 DUF3631 domain-containing protein -
LVJ68_RS14100 (LVJ68_14100) 2980090..2980482 - 393 WP_003899417.1 DUF2742 domain-containing protein -
LVJ68_RS14105 (LVJ68_14105) 2980479..2980739 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
LVJ68_RS14110 (LVJ68_14110) 2980756..2981118 - 363 WP_003900543.1 hypothetical protein -
LVJ68_RS14115 (LVJ68_14115) 2981121..2982248 - 1128 WP_003899420.1 site-specific integrase -
LVJ68_RS14120 (LVJ68_14120) 2982393..2982620 - 228 WP_003899421.1 hypothetical protein -
LVJ68_RS14125 (LVJ68_14125) 2982617..2983006 - 390 WP_003899422.1 hypothetical protein -
LVJ68_RS14130 (LVJ68_14130) 2982912..2983184 + 273 WP_003900544.1 hypothetical protein -
LVJ68_RS14135 (LVJ68_14135) 2983283..2983516 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2973339..2982248 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T228767 WP_003899414.1 NZ_CP089773:c2978339-2978016 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T228767 NZ_CP124343:c827241-826864 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCAACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAAAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT228767 WP_003899415.1 NZ_CP089773:c2978664-2978419 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT228767 NZ_CP124343:c827698-827318 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGGGGCCGGT
TCAACAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGGTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References