Detailed information of TA system TA022874

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 864199..864701
• Replicon: chromosome
• Accession: NC_010694
• Organism: Erwinia tasmaniensis Et1/99

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: B2VD73
• Locus tag: ETA_RS04950
• Protein ID: WP_012440518.1
• Coordinates: 864447..864701 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: ETA_RS04945
• Protein ID: WP_042959259.1
• Coordinates: 864199..864450 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ETA_RS04935	860593..861252	+	660	WP_042958671.1	class I SAM-dependent methyltransferase	-
ETA_RS04940	861664..863703	-	2040	WP_012440517.1	choline transporter	-
ETA_RS04945	864199..864450	+	252	WP_042959259.1	YoeB-YefM toxin-antitoxin system antitoxin YefM	Antitoxin
ETA_RS04950	864447..864701	+	255	WP_012440518.1	Txe/YoeB family addiction module toxin	Toxin
ETA_RS04955	865096..866028	+	933	WP_042958674.1	FAD-dependent oxidoreductase	-
ETA_RS04960	866025..866222	+	198	WP_012440520.1	sulfur carrier protein ThiS	-
ETA_RS04965	866226..866996	+	771	WP_012440521.1	thiazole synthase	-
ETA_RS04970	867000..867965	+	966	WP_012440522.1	ThiF family adenylyltransferase	-
ETA_RS04975	868201..868482	+	282	WP_012440523.1	VF530 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9907.25 Da
• Isoelectric Point: 8.8975

>T22874 WP_012440518.1 NC_010694:864447-864701 [Erwinia tasmaniensis Et1/99]
VKLTWSAEAWEDYLNWQEADKRTVKKINELIKDTSRIPFEGKGKPEPLKHNLAGFWSRRITSEHRLVYAVSDDSLLIASC
RYHY

Nucleotide

• Length: 255 bp

>T22874 NC_010694:864447-864701 [Erwinia tasmaniensis Et1/99]
GTGAAGCTGACATGGTCCGCTGAAGCATGGGAAGACTATCTTAACTGGCAGGAAGCGGACAAAAGAACGGTAAAAAAGAT
AAATGAGCTCATTAAGGATACCAGCAGGATACCTTTTGAAGGAAAAGGGAAGCCTGAGCCTCTGAAACATAACCTGGCTG
GTTTCTGGTCTCGAAGGATCACTTCCGAGCATCGGCTGGTCTACGCCGTCAGCGATGATTCTTTACTCATCGCCTCCTGC
CGTTATCACTATTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9391.58 Da
• Isoelectric Point: 4.5983

>AT22874 WP_042959259.1 NC_010694:864199-864450 [Erwinia tasmaniensis Et1/99]
MRAISYSEARQNLSATMLQTVEDRSPVLITRQNGESCVLMSLEEYNSLEETAYLLRSPKNARRLIDSVESLQSGKGVERD
IIE

Nucleotide

• Length: 252 bp

>AT22874 NC_010694:864199-864450 [Erwinia tasmaniensis Et1/99]
ATGAGAGCGATAAGTTACAGCGAAGCAAGGCAAAATCTGTCTGCAACAATGCTTCAGACAGTCGAGGACAGGTCACCTGT
GCTGATCACCCGCCAGAACGGTGAATCATGCGTGCTGATGTCTCTCGAAGAATATAATTCCCTCGAAGAAACCGCTTATC
TCCTTCGATCGCCCAAGAATGCGCGCAGGCTTATCGACTCCGTAGAAAGCCTGCAAAGCGGTAAAGGTGTAGAAAGGGAC
ATCATTGAGTGA

Structures

Toxin

• AlphaFold DB: B2VD73