Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 5069066..5069712 Replicon chromosome
Accession NZ_CP089762
Organism Klebsiella pneumoniae strain HKC1

Toxin (Protein)


Gene name higB Uniprot ID W8UNE1
Locus tag LVO51_RS24975 Protein ID WP_002920560.1
Coordinates 5069066..5069413 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag LVO51_RS24980 Protein ID WP_002920557.1
Coordinates 5069413..5069712 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVO51_RS24965 (LVO51_24930) 5064992..5066425 + 1434 WP_002920564.1 glycogen synthase GlgA -
LVO51_RS24970 (LVO51_24935) 5066443..5068890 + 2448 WP_002920561.1 glycogen phosphorylase -
LVO51_RS24975 (LVO51_24940) 5069066..5069413 + 348 WP_002920560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LVO51_RS24980 (LVO51_24945) 5069413..5069712 + 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
LVO51_RS24985 (LVO51_24950) 5069775..5071283 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
LVO51_RS24990 (LVO51_24955) 5071488..5071817 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
LVO51_RS24995 (LVO51_24960) 5071868..5072698 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
LVO51_RS25000 (LVO51_24965) 5072748..5073506 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13502.56 Da        Isoelectric Point: 6.2300

>T228594 WP_002920560.1 NZ_CP089762:5069066-5069413 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRACFAFDPLRKAI
VLCVGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T228594 NZ_CP124326:188058-188165 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT228594 WP_002920557.1 NZ_CP089762:5069413-5069712 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT228594 NZ_CP124326:c188009-187944 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CBY5

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References