Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4702561..4703242 Replicon chromosome
Accession NZ_CP089745
Organism Pseudomonas aeruginosa strain Pa608

Toxin (Protein)


Gene name higB Uniprot ID V6AKP0
Locus tag LRP95_RS21875 Protein ID WP_003111825.1
Coordinates 4702877..4703242 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1C7BMJ2
Locus tag LRP95_RS21870 Protein ID WP_003159602.1
Coordinates 4702561..4702884 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRP95_RS21835 4698520..4699203 - 684 WP_003120766.1 TetR/AcrR family transcriptional regulator -
LRP95_RS21840 4699291..4700169 + 879 WP_014603214.1 hypothetical protein -
LRP95_RS21850 4700772..4700999 + 228 WP_014603215.1 hypothetical protein -
LRP95_RS21855 4701014..4701939 - 926 Protein_4330 tyrosine-type recombinase/integrase -
LRP95_RS21860 4701939..4702331 - 393 Protein_4331 hypothetical protein -
LRP95_RS21865 4702326..4702445 + 120 Protein_4332 IS5/IS1182 family transposase -
LRP95_RS21870 4702561..4702884 - 324 WP_003159602.1 XRE family transcriptional regulator Antitoxin
LRP95_RS21875 4702877..4703242 - 366 WP_003111825.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LRP95_RS21880 4703533..4703707 - 175 Protein_4335 hypothetical protein -
LRP95_RS21885 4703914..4704186 + 273 WP_014603216.1 hypothetical protein -
LRP95_RS21890 4704216..4704641 - 426 WP_003116492.1 VOC family protein -
LRP95_RS21895 4704742..4705626 + 885 WP_003085663.1 LysR substrate-binding domain-containing protein -
LRP95_RS21900 4705599..4706552 - 954 WP_003085661.1 LysR substrate-binding domain-containing protein -
LRP95_RS21905 4706773..4707207 + 435 WP_003116494.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-63)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13880.24 Da        Isoelectric Point: 4.8219

>T228576 WP_003111825.1 NZ_CP089745:c4703242-4702877 [Pseudomonas aeruginosa]
VAWDIEYTDEFGDWWGSLSEDEQESLAVTVRLLEERGPSLGHPHSSGINGSRHGHMRELRTQHGGRPFRTLYAFDPRRSA
ILLIGGDKTGDDRWYELNVPIADRLYDEHLHQLREEGLIDG

Download         Length: 366 bp

>T228576 NZ_CP124324:c827241-826864 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCAACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAAAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11882.71 Da        Isoelectric Point: 6.4751

>AT228576 WP_003159602.1 NZ_CP089745:c4702884-4702561 [Pseudomonas aeruginosa]
MAKKFSDLRAQMSPEGQARVEAKAQELLAEMPLNELRQARGLSQKMLSEVLHVQQPAIAKMERRTDMYISTLRSHIEAMG
GQLEVIARFPDGAVKISNFADIEEAGA

Download         Length: 324 bp

>AT228576 NZ_CP124324:c827698-827318 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGGGGCCGGT
TCAACAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGGTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AKP0

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BMJ2

References