Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2962467..2963115 Replicon chromosome
Accession NZ_CP089611
Organism Mycobacterium tuberculosis strain I0004240-3

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag LVJ90_RS13965 Protein ID WP_003899414.1
Coordinates 2962467..2962790 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag LVJ90_RS13970 Protein ID WP_003899415.1
Coordinates 2962870..2963115 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ90_RS13935 (LVJ90_13935) 2957790..2958788 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
LVJ90_RS13940 (LVJ90_13940) 2958802..2959266 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
LVJ90_RS13945 (LVJ90_13945) 2959254..2959505 + 252 WP_003908028.1 hypothetical protein -
LVJ90_RS13950 (LVJ90_13950) 2959676..2961115 - 1440 WP_003899411.1 phage major capsid protein -
LVJ90_RS13955 (LVJ90_13955) 2961123..2961656 - 534 WP_003899412.1 HK97 family phage prohead protease -
LVJ90_RS13960 (LVJ90_13960) 2961809..2962300 - 492 WP_003900541.1 phage terminase small subunit P27 family -
LVJ90_RS13965 (LVJ90_13965) 2962467..2962790 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
LVJ90_RS13970 (LVJ90_13970) 2962870..2963115 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
LVJ90_RS13975 (LVJ90_13975) 2963112..2964539 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
LVJ90_RS13980 (LVJ90_13980) 2964541..2964933 - 393 WP_003899417.1 DUF2742 domain-containing protein -
LVJ90_RS13985 (LVJ90_13985) 2964930..2965190 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
LVJ90_RS13990 (LVJ90_13990) 2965207..2965569 - 363 WP_003900543.1 hypothetical protein -
LVJ90_RS13995 (LVJ90_13995) 2965572..2966699 - 1128 WP_003899420.1 site-specific integrase -
LVJ90_RS14000 (LVJ90_14000) 2966844..2967071 - 228 WP_003899421.1 hypothetical protein -
LVJ90_RS14005 (LVJ90_14005) 2967068..2967457 - 390 WP_003899422.1 hypothetical protein -
LVJ90_RS14010 (LVJ90_14010) 2967363..2967635 + 273 WP_003900544.1 hypothetical protein -
LVJ90_RS14015 (LVJ90_14015) 2967734..2967967 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2957790..2966699 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T228549 WP_003899414.1 NZ_CP089611:c2962790-2962467 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T228549 NZ_CP124322:188541-188648 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGTTCCGGTCATTACTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT228549 WP_003899415.1 NZ_CP089611:c2963115-2962870 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT228549 NZ_CP124322:c188484-188427 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References