Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Gp49-HTH_37 |
| Location | 2202884..2203752 | Replicon | chromosome |
| Accession | NZ_CP089611 | ||
| Organism | Mycobacterium tuberculosis strain I0004240-3 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | P9WJA4 |
| Locus tag | LVJ90_RS10260 | Protein ID | WP_010886136.1 |
| Coordinates | 2202884..2203261 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | G0TLM0 |
| Locus tag | LVJ90_RS10265 | Protein ID | WP_003409886.1 |
| Coordinates | 2203303..2203752 (+) | Length | 150 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LVJ90_RS10210 (LVJ90_10220) | 2198673..2199125 | - | 453 | WP_003899095.1 | lipoprotein | - |
| LVJ90_RS10215 (LVJ90_10225) | 2199189..2199590 | + | 402 | WP_003409869.1 | hypothetical protein | - |
| LVJ90_RS10220 (LVJ90_10230) | 2199583..2199765 | - | 183 | WP_003409870.1 | hypothetical protein | - |
| LVJ90_RS10225 (LVJ90_10235) | 2199879..2200229 | - | 351 | WP_003899096.1 | hypothetical protein | - |
| LVJ90_RS10230 (LVJ90_10240) | 2200240..2201142 | - | 903 | WP_003899097.1 | hypothetical protein | - |
| LVJ90_RS10235 (LVJ90_10245) | 2201163..2201354 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| LVJ90_RS10240 (LVJ90_10250) | 2201355..2201651 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| LVJ90_RS10245 (LVJ90_10255) | 2201891..2202106 | + | 216 | WP_003409878.1 | antitoxin | - |
| LVJ90_RS10250 (LVJ90_10260) | 2202103..2202414 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| LVJ90_RS10255 (LVJ90_10265) | 2202388..2202909 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| LVJ90_RS10260 (LVJ90_10270) | 2202884..2203261 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | Toxin |
| LVJ90_RS10265 (LVJ90_10275) | 2203303..2203752 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | Antitoxin |
| LVJ90_RS10270 (LVJ90_10280) | 2203749..2204294 | + | 546 | WP_003899098.1 | SecB-like chaperone | - |
| LVJ90_RS10275 (LVJ90_10285) | 2204183..2204797 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| LVJ90_RS10280 (LVJ90_10290) | 2204846..2205142 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| LVJ90_RS10285 (LVJ90_10295) | 2205139..2205390 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| LVJ90_RS10290 (LVJ90_10300) | 2205377..2205871 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| LVJ90_RS10295 (LVJ90_10305) | 2206031..2206438 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| LVJ90_RS10300 (LVJ90_10310) | 2206442..2206714 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| LVJ90_RS10305 (LVJ90_10315) | 2206747..2207967 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14397.77 Da Isoelectric Point: 10.8862
>T228533 WP_010886136.1 NZ_CP089611:2202884-2203261 [Mycobacterium tuberculosis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
Download Length: 378 bp
>T228533 NZ_CP124320:1149568-1149882 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA
Antitoxin
Download Length: 150 a.a. Molecular weight: 16760.16 Da Isoelectric Point: 8.0771
>AT228533 WP_003409886.1 NZ_CP089611:2203303-2203752 [Mycobacterium tuberculosis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
Download Length: 450 bp
>AT228533 NZ_CP124320:1149332-1149565 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|