Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2986315..2986963 Replicon chromosome
Accession NZ_CP089610
Organism Mycobacterium tuberculosis strain I0004290-8

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag LVJ91_RS14075 Protein ID WP_003899414.1
Coordinates 2986315..2986638 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag LVJ91_RS14080 Protein ID WP_003899415.1
Coordinates 2986718..2986963 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ91_RS14045 (LVJ91_14050) 2981638..2982636 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
LVJ91_RS14050 (LVJ91_14055) 2982650..2983114 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
LVJ91_RS14055 (LVJ91_14060) 2983102..2983353 + 252 WP_003908028.1 hypothetical protein -
LVJ91_RS14060 (LVJ91_14065) 2983524..2984963 - 1440 WP_003899411.1 phage major capsid protein -
LVJ91_RS14065 (LVJ91_14070) 2984971..2985504 - 534 WP_003899412.1 HK97 family phage prohead protease -
LVJ91_RS14070 (LVJ91_14075) 2985657..2986148 - 492 WP_003900541.1 phage terminase small subunit P27 family -
LVJ91_RS14075 (LVJ91_14080) 2986315..2986638 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
LVJ91_RS14080 (LVJ91_14085) 2986718..2986963 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
LVJ91_RS14085 (LVJ91_14090) 2986960..2988387 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
LVJ91_RS14090 (LVJ91_14095) 2988389..2988781 - 393 WP_003899417.1 DUF2742 domain-containing protein -
LVJ91_RS14095 (LVJ91_14100) 2988778..2989038 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
LVJ91_RS14100 (LVJ91_14105) 2989055..2989417 - 363 WP_003900543.1 hypothetical protein -
LVJ91_RS14105 (LVJ91_14110) 2989420..2990547 - 1128 WP_003899420.1 site-specific integrase -
LVJ91_RS14110 (LVJ91_14115) 2990692..2990919 - 228 WP_003899421.1 hypothetical protein -
LVJ91_RS14115 (LVJ91_14120) 2990916..2991305 - 390 WP_003899422.1 hypothetical protein -
LVJ91_RS14120 (LVJ91_14125) 2991211..2991483 + 273 WP_003900544.1 hypothetical protein -
LVJ91_RS14125 (LVJ91_14130) 2991582..2991815 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2981638..2990547 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(15-92)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T228488 WP_003899414.1 NZ_CP089610:c2986638-2986315 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T228488 NZ_CP123983:872243-872449 [Staphylococcus haemolyticus]
ATGAACTTTAGTGAAATTAGAATTAGTGAATTAAATACTGAAGAGCAAGCTAATTCACTCCAACATAGACTTGAGAAGAT
GATAGGTGTAGATGAAGTAATTGTAGAACTAAATGACCAATTAGTTAAAATTTCTTATGAAACACCTACGAATTTAAATA
GTATTGAAAAAGAAATTTATGATGATGGTTATAAGGTATTAGGTTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT228488 WP_003899415.1 NZ_CP089610:c2986963-2986718 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT228488 NZ_CP123983:871938-872231 [Staphylococcus haemolyticus]
TTGAATAATCATGAAAATGCACATCATTCCGATCAAATTAAAATGAATTTAAAATCAAGACTTAATCGTATTGAAGGGCA
AGTTAGAGCGATTAATCGCATGATTGAAGAAGATGTATACTGTGATGACGTGCTAACTCAAATTAGAGCTACAAGATCAG
CTTTAAATAGTGTGGCCACTAAGTTGCTAGATCATCATATGAAAAGCTGTATCATGGATAAAGTGAATAACGGCGCTCAA
GAAGAAGCGATGGAAGAATTGTTAGTGACTTTTCAAAAATTAATGAAAGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References