Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 86941..87665 | Replicon | plasmid pKP29499-2 |
| Accession | NZ_CP089600 | ||
| Organism | Klebsiella pneumoniae strain KP29499 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A6B7Q840 |
| Locus tag | LVE73_RS28270 | Protein ID | WP_065905253.1 |
| Coordinates | 87354..87665 (-) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | LVE73_RS28265 | Protein ID | WP_049010942.1 |
| Coordinates | 86941..87357 (-) | Length | 139 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LVE73_RS28235 (LVE73_28235) | 82215..82523 | - | 309 | WP_071599372.1 | DUF5983 family protein | - |
| LVE73_RS28240 (LVE73_28240) | 82583..83404 | - | 822 | WP_072122811.1 | DUF932 domain-containing protein | - |
| LVE73_RS28245 (LVE73_28245) | 84230..85053 | - | 824 | Protein_90 | N-6 DNA methylase | - |
| LVE73_RS28250 (LVE73_28250) | 85102..85248 | - | 147 | WP_004152750.1 | hypothetical protein | - |
| LVE73_RS28255 (LVE73_28255) | 85343..85690 | - | 348 | WP_072122771.1 | hypothetical protein | - |
| LVE73_RS28260 (LVE73_28260) | 85747..86100 | - | 354 | WP_072122772.1 | hypothetical protein | - |
| LVE73_RS28265 (LVE73_28265) | 86941..87357 | - | 417 | WP_049010942.1 | helix-turn-helix domain-containing protein | Antitoxin |
| LVE73_RS28270 (LVE73_28270) | 87354..87665 | - | 312 | WP_065905253.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| LVE73_RS28275 (LVE73_28275) | 87772..87996 | - | 225 | WP_042922612.1 | hypothetical protein | - |
| LVE73_RS28280 (LVE73_28280) | 88007..88219 | - | 213 | WP_072122774.1 | hypothetical protein | - |
| LVE73_RS28285 (LVE73_28285) | 88281..88607 | - | 327 | WP_072122773.1 | hypothetical protein | - |
| LVE73_RS28290 (LVE73_28290) | 89243..89593 | - | 351 | WP_014386186.1 | hypothetical protein | - |
| LVE73_RS28295 (LVE73_28295) | 89590..89862 | - | 273 | WP_072122775.1 | hypothetical protein | - |
| LVE73_RS28300 (LVE73_28300) | 90516..90812 | - | 297 | WP_077263634.1 | hypothetical protein | - |
| LVE73_RS28305 (LVE73_28305) | 90885..91262 | - | 378 | WP_228136766.1 | hypothetical protein | - |
| LVE73_RS28310 (LVE73_28310) | 91373..91696 | - | 324 | WP_072122776.1 | theronine dehydrogenase | - |
| LVE73_RS28315 (LVE73_28315) | 91700..92422 | - | 723 | WP_072122777.1 | plasmid SOS inhibition protein A | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | blaTEM-1B / aph(6)-Id / aph(3'')-Ib / sul2 / blaCTX-M-71 / qnrS1 | - | 1..136701 | 136701 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12525.37 Da Isoelectric Point: 9.9242
>T228432 WP_065905253.1 NZ_CP089600:c87665-87354 [Klebsiella pneumoniae]
VHVISRAPFDEAARHYPNDAVAIDDTYRVLKRVVAKKPDELKRYFTSLDRMKYREKWWVIDIGGNNLRMMFFADFERGKI
FVKHITTHAEYDRLTKYYREHKE
VHVISRAPFDEAARHYPNDAVAIDDTYRVLKRVVAKKPDELKRYFTSLDRMKYREKWWVIDIGGNNLRMMFFADFERGKI
FVKHITTHAEYDRLTKYYREHKE
Download Length: 312 bp
>T228432 NZ_CP123953:c144205-143924 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCTTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTAA
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCTTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTAA
Antitoxin
Download Length: 139 a.a. Molecular weight: 15438.52 Da Isoelectric Point: 4.4711
>AT228432 WP_049010942.1 NZ_CP089600:c87357-86941 [Klebsiella pneumoniae]
MIFSDAIKAANDLASIVPLLGGSSSRKDYEEALKLVEYLLEHDPDSPLVDMLTARIDAWEDNAVEFEEFNTRIEAGKNGV
SLLRVLMQQHGLSQSDFENEIGKKSLVSRILSGERSLTLDHMRALANRFQIPVSMFVD
MIFSDAIKAANDLASIVPLLGGSSSRKDYEEALKLVEYLLEHDPDSPLVDMLTARIDAWEDNAVEFEEFNTRIEAGKNGV
SLLRVLMQQHGLSQSDFENEIGKKSLVSRILSGERSLTLDHMRALANRFQIPVSMFVD
Download Length: 417 bp
>AT228432 NZ_CP123953:c144429-144202 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|