Detailed information of TA system TA022843

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 928546..928771
• Replicon: chromosome
• Accession: NC_010658
• Organism: Shigella boydii CDC 3083-94

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: -
• Locus tag: SBBS512_RS06825
• Protein ID: WP_000935258.1
• Coordinates: 928546..928758 (-)
• Length: 71 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	928713..928771 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SBBS512_RS06790	923694..924850	+	1157	WP_129592860.1	IS3 family transposase	-
SBBS512_RS06795	924894..925193	-	300	Protein_900	DUF968 domain-containing protein	-
SBBS512_RS06800	925233..926771	-	1539	WP_000099170.1	IS66-like element ISEc22 family transposase	-
SBBS512_RS06805	926820..927167	-	348	WP_000612626.1	IS66 family insertion sequence element accessory protein TnpB	-
SBBS512_RS06810	927164..927544	-	381	WP_001333468.1	IS66 family insertion sequence hypothetical protein	-
SBBS512_RS06815	927637..928098	-	462	Protein_904	hypothetical protein	-
SBBS512_RS06820	928100..928378	-	279	WP_000929754.1	hypothetical protein	-
SBBS512_RS06825	928546..928758	-	213	WP_000935258.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	928713..928771	+	59	-	-	Antitoxin
SBBS512_RS06840	929353..929706	-	354	WP_071821547.1	hypothetical protein	-
SBBS512_RS06845	929839..930219	+	381	WP_001333468.1	IS66 family insertion sequence hypothetical protein	-
SBBS512_RS06850	930216..930563	+	348	WP_000612626.1	IS66 family insertion sequence element accessory protein TnpB	-
SBBS512_RS06855	930612..932150	+	1539	WP_000099170.1	IS66-like element ISEc22 family transposase	-
SBBS512_RS06860	932147..932506	+	360	WP_073692993.1	3'-5' exoribonuclease	-
SBBS512_RS06865	932565..932768	+	204	WP_048815025.1	DUF4224 domain-containing protein	-
SBBS512_RS06870	932768..933123	+	356	Protein_913	integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	rhs/PAAR / rhs/PAAR / ipaH9.8	805443..947422	141979
	-	inside	IScluster/Tn	-	-	922869..934324	11455

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 71 a.a.
• Molecular weight: 7856.42 Da
• Isoelectric Point: 8.7469

>T22843 WP_000935258.1 NC_010658:c928758-928546 [Shigella boydii CDC 3083-94]
MLNTCRLASYVPKGKEKQAMKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 213 bp

>T22843 NC_010658:c928758-928546 [Shigella boydii CDC 3083-94]
ATGCTGAACACATGTAGGTTAGCCTCTTACGTGCCGAAAGGCAAGGAGAAGCAGGCTATGAAGCAGCAAAAGGCGATGTT
AATCGCCCTTATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAAAGACCTCTGCGAGGTACGAATCC
GAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT22843 NC_010658:928713-928771 [Shigella boydii CDC 3083-94]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Structures

Antitoxin