Detailed information of TA system TA228378

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2354659..2354843
• Replicon: chromosome
• Accession: NZ_CP089586
• Organism: Staphylococcus aureus strain E1185_IV_ST12

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: LUU82_RS11625
• Protein ID: WP_000482647.1
• Coordinates: 2354659..2354766 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2354783..2354843 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LUU82_RS11600	2350031..2350504	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
LUU82_RS11605	2350627..2351838	-	1212	WP_001191923.1	multidrug effflux MFS transporter	-
LUU82_RS11610	2352020..2352679	-	660	WP_000831298.1	membrane protein	-
LUU82_RS11615	2352739..2353881	-	1143	WP_001176863.1	glycerate kinase	-
LUU82_RS11620	2354139..2354525	+	387	WP_000779347.1	flippase GtxA	-
LUU82_RS11625	2354659..2354766	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2354783..2354843	-	61	-	-	Antitoxin
LUU82_RS11630	2355470..2357233	+	1764	WP_001064816.1	ABC transporter ATP-binding protein	-
LUU82_RS11635	2357258..2358991	+	1734	WP_000486494.1	ABC transporter ATP-binding protein	-
LUU82_RS11640	2359258..2359389	+	132	WP_223223631.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T228378 WP_000482647.1 NZ_CP089586:2354659-2354766 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T228378 NZ_CP123897:c1003488-1003180 [Methylomonas sp. UP202]
ATGGCGCGTTTCGAGGTCTACGGCAATAACAGCGACAAATCCGCCGATGCACCCTTTTTCTTGGATGTGCAAAGCGATGT
TTTGAATGGCTTGGATAGCCGGATTGTGGTCCCGTTACGGCGGCGCGACCGCTTCCGGGCGATTTCGTTACCGGCTAATT
TAATGCCGGTCTTGGACATCGACGGCGTCGAATACGTTTTGGAAATGCCGGAATTGGCTGCGGTTCCGGTAAGAATATTG
ACGGAGCCGGTAACATCGCTGGAGGCTTTGCGGTTTGAGATTAGGGCGGCGTTGGATTTTTTGTTTTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT228378 NZ_CP089586:c2354843-2354783 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin